典型文献
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
文献摘要：
Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and pro-gression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for non-alcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical interven-tion.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and devel-opment of HCC therapy targeting metabolism are discussed.
文献关键词：
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作者姓名：
Danyu Du;Chan Liu;Mengyao Qin;Xiao Zhang;Tao Xi;Shengtao Yuan;Haiping Hao;Jing Xiong
作者机构：
Department of Pharmacology,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Research Center of Biotechnology,School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China;Jiangsu Key Laboratory of Drug Screening,China Pharmaceutical University,Nanjing 210009,China;State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China;Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,China
文献出处：
引用格式：
[1]Danyu Du;Chan Liu;Mengyao Qin;Xiao Zhang;Tao Xi;Shengtao Yuan;Haiping Hao;Jing Xiong-.Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma)[J].药学学报（英文版）,2022(02):558-580
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Metabolic,dysregulation,emerging,therapeutical,targets,hepatocellular,carcinoma,Hepatocellular,HCC,aggressive,human,cancer,increasing,incidence,worldwide,Multiple,efforts,have,been,made,explore,pharmaceutical,therapies,such,targeted,tyrosine,kinase,inhibitors,immune,combination,chemotherapy,However,limitations,exist,current,strategies,including,chemoresistance,instance,Tumor,initiation,gression,driven,reprogramming,metabolism,particular,during,development,Recently,metabolic,associated,fatty,liver,disease,MAFLD,reappraisal,new,nomenclature,alcoholic,NAFLD,indicates,growing,appreciation,pathogenesis,thereby,suggesting,targeting,abnormal,treatment,In,this,review,introduce,directions,highlighting,glucose,acid,amino,glutamine,which,are,suitable,interven,We,also,summarize,agents,studies,deregulated,Furthermore,opportunities,challenges,discovery,discussed
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0.627439
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