典型文献
Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota
文献摘要：
The role of gut-kidney crosstalk in the progression of diabetic nephropathy(DN)is receiving increasing concern.On one hand,the decline in renal function increases circulating uremic toxins and affects the composition and function of gut microbiota.On the other hand,intestinal dysbiosis destroys the epithelial barrier,leading to increased exposure to endotoxins,thereby exacerbating kidney damage by inducing systemic inflammation.Dietary inven-tions,such as higher fiber intake,prebiotics,probiotics,postbiotics,fecal microbial transplantation(FMT),and engineering bacteria and phages,are potential microbiota-based therapies for DN.Furthermore,novel diabetic agents,such as glucagon-like peptide-1(GLP-1)receptor agonists,dipeptidyl peptidase-4(DPP-4)inhibitors,and sodium-dependent glucose transporter-2(SGLT-2)inhibitors,may affect the progression of DN partly through gut microbiota.In the current review,we mainly summarize the evidence concerning the gut-kidney axis in the ad-vancement of DN and discuss therapies targeting the gut microbiota,expecting to provide new insight into the clinical treatment of DN.
文献关键词：
中图分类号：
作者姓名：
Yinhua Ni;Liujie Zheng;Sujie Nan;Lehui Ke;Zhengwei Fu;Juan Jin
作者机构：
College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310032,China;Urology&Nephrology Center,Department of Nephrology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China
文献出处：
引用格式：
[1]Yinhua Ni;Liujie Zheng;Sujie Nan;Lehui Ke;Zhengwei Fu;Juan Jin-.Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota)[J].生物化学与生物物理学报（英文版）,2022(10):1406-1420
A类：
Enterorenal,crosstalks,endotoxins,inven,postbiotics,vancement
B类：
diabetic,nephropathy,novel,therapeutics,targeting,gut,microbiota,role,kidney,progression,DN,receiving,increasing,On,one,hand,decline,function,increases,circulating,uremic,affects,composition,other,intestinal,dysbiosis,destroys,epithelial,barrier,leading,increased,exposure,thereby,exacerbating,damage,inducing,systemic,inflammation,Dietary,tions,such,higher,fiber,intake,prebiotics,probiotics,fecal,microbial,transplantation,FMT,engineering,bacteria,phages,are,potential,therapies,Furthermore,agents,glucagon,like,peptide,GLP,receptor,agonists,dipeptidyl,peptidase,DPP,inhibitors,sodium,dependent,glucose,transporter,SGLT,may,partly,through,In,current,review,we,mainly,summarize,evidence,concerning,axis,discuss,expecting,provide,new,insight,into,clinical,treatment
AB值：
0.600566
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
