典型文献
New perspectives on ferroptosis and its role in hepatocellular carcinoma
文献摘要：
For a long time, the morbidity and mortality rates of hepatocellular carcinoma (HCC) have remained high. Since the concept of ferroptosis was introduced in 2012, researchers’ perspectives have shifted toward finding novel ferroptosis-related treatment strategies, especially for tumors that are resistant to apoptosis. In recent years, there have been an increasing number of studies on ferroptosis, and these studies have found that ferroptosis has great potential and promise for cancer treatment. Ferroptosis is a kind of regulated cell death (RCD); unlike apoptosis, ferroptosis is an iron-dependent type of RCD driven by lipid peroxidation. The whole process of ferroptosis mainly revolves around three pathways (system x
c-/ glutathione peroxidase 4 [GPX4]), lipid peroxidation, and iron metabolism), which are also regulated by various metabolic factors. This review will attempt to analyze the relationship between the system x
c-/GPX4 pathway, lipid peroxidation, iron metabolism, and ferroptosis from three aspects (triggering, execution, and regulation), and the regulatory factors for ferroptosis will be summarized. In this review, we will also illustrate the relationship between ferroptosis and tumors as well as its application in tumors from the perspective of HCC. Finally, we will summarize the current limitations and needs and provide perspectives related to the focus of development in the future.
文献关键词：
Ferroptosis;Hepatocellular carcinoma;Molecular targets
中图分类号：
作者姓名：
Cong Tianhao;Luo Yingen;Fu Yan;Liu Yu;Li Yujie;Li Xiao
作者机构：
Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
文献出处：
引用格式：
[1]Cong Tianhao;Luo Yingen;Fu Yan;Liu Yu;Li Yujie;Li Xiao-.New perspectives on ferroptosis and its role in hepatocellular carcinoma)[J].中华医学杂志（英文版）,2022(18):2157-2166
A类：
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B类：
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AB值：
0.544415
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