典型文献
Ascyrones A-E,type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron
文献摘要：
Five new polycyclic polyprenylated acylphloroglucinols(1-5),ascyrones A-E,and four known compounds(6-9)were isolated from the aerial parts of Hypericum ascyron.All of the isolates containing a bicyclo[3.3.1]nonane-2,4,9-trione core and a benzoyl group,belonged to type B bicyclic polyprenylated acylphloroglucinols(BPAPs).Their structures and absolute configurations were established based on spectroscopic analyses and calculated electronic circular dichroism(ECD)data.The anti-inflammatory,neuroprotective and cytotoxicity activities of compounds 1-4 and 6-9 were evaluated.Compound 6 exhibited obvious anti-inflammat-ory activity in lipopolysaccharide(LPS)-induced RAW264.7 cells.Compounds 1 and 9 exhibited slight cytotoxicity against Hep3B cells.Meanwhile,compound 1 showed mild neuroprotective activity against corticosterone(CORT)-induced PC 12 cell damage at 10 umol-L-1.
文献关键词：
中图分类号：
作者姓名：
DENG Xin;XIA Jing;QIAN Meng-Yu;WANG Xiu-Rong;HU Bo;LIU Xue-Song;WU Lin
作者机构：
School of Pharmacy,Anhui Medical University;Inflammation and Immune Mediated Disease Laboratory of Anhui Province,Hefei 230032,China
文献出处：
引用格式：
[1]DENG Xin;XIA Jing;QIAN Meng-Yu;WANG Xiu-Rong;HU Bo;LIU Xue-Song;WU Lin-.Ascyrones A-E,type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron)[J].中国天然药物,2022(06):473-480
A类：
Ascyrones,ployprenylated,acylphloroglucinol,ascyron,polyprenylated,acylphloroglucinols,ascyrones,trione,BPAPs,inflammat
B类：
type,bicyclic,derivatives,from,Hypericum,Five,new,polycyclic,four,known,compounds,were,isolated,aerial,parts,All,isolates,containing,bicyclo,nonane,core,benzoyl,group,belonged,Their,structures,absolute,configurations,established,spectroscopic,analyses,calculated,electronic,circular,dichroism,ECD,data,anti,inflammatory,neuroprotective,cytotoxicity,activities,evaluated,exhibited,obvious,activity,lipopolysaccharide,LPS,induced,RAW264,cells,Compounds,slight,against,Hep3B,Meanwhile,showed,mild,corticosterone,CORT,damage,umol
AB值：
0.549164
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