典型文献
Distachydrimanes A-F,phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum
文献摘要：
By integrating one strain-many compounds(OSMAC)and LC-MS-based molecular networking strategies,distachydrimanes A-F(1-6),six novel phenylspirodrimane dimers and hybrids representing two types of unprecedented terpenoid-polyketide hybrid skeletons,were isolated from the modified fermented rice substrate of a coral-derived fungus Stachybotrys chartarum.All the structures incorporating their absolute configurations were elucidated based on comprehensive spectroscopic analyses,mainly including HRES-IMS and NMR data,single-crystal X-ray diffraction(Cu Kα),and comparison of the experimental elec-tronic circular dichroism(ECD)data.Architecturally,compounds 1-6 represent an unprecedented class of dimeric phenylspirodrimanes with an unexpected C-18-C-23'linkage,of which compounds 1-3 also fea-ture an unexpected 5-methyl-1,3-benzenediol moiety via a carbon-carbon linkage.The bioactivity assay demonstrated that compounds 1,5 and 6 induced cell proliferation inhibition,G0/G1 cell cycle arrest,senescence and mitochondrial-mediated apoptosis in L1210 cells,highlighting their potentials as a new category of anticancer agents.
文献关键词：
中图分类号：
作者姓名：
Shuang Lin;Jianzheng Huang;Hanxiao Zeng;Qingyi Tong;Xueke Zhang;Beiye Yang;Ying Ye;Jianping Wang;Zhengxi Hu;Yonghui Zhang
作者机构：
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
文献出处：
引用格式：
[1]Shuang Lin;Jianzheng Huang;Hanxiao Zeng;Qingyi Tong;Xueke Zhang;Beiye Yang;Ying Ye;Jianping Wang;Zhengxi Hu;Yonghui Zhang-.Distachydrimanes A-F,phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum)[J].中国化学快报（英文版）,2022(10):4587-4594
A类：
Distachydrimanes,phenylspirodrimane,chartarum,distachydrimanes,Architecturally,phenylspirodrimanes
B类：
dimers,hybrids,cytotoxic,from,coral,derived,fungus,Stachybotrys,By,integrating,one,strain,many,compounds,OSMAC,LC,molecular,networking,strategies,six,novel,representing,types,unprecedented,terpenoid,polyketide,skeletons,were,isolated,modified,fermented,rice,substrate,All,structures,incorporating,their,absolute,configurations,elucidated,comprehensive,spectroscopic,analyses,mainly,including,HRES,IMS,NMR,data,single,crystal,ray,diffraction,comparison,experimental,elec,tronic,circular,dichroism,ECD,class,dimeric,unexpected,linkage,which,also,fea,methyl,benzenediol,moiety,via,carbon,bioactivity,assay,demonstrated,that,induced,proliferation,inhibition,G0,G1,cycle,arrest,senescence,mitochondrial,mediated,apoptosis,L1210,cells,highlighting,potentials,new,category,anticancer,agents
AB值：
0.652279
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
