Traditional Chinese medicines(TCMs)have continued to be a treasure trove.The study of chemodiversity and versatility of bioactivities has always been an important content of pharmacophylogeny.There is amazing progress in the discovery and research of natural components with novel structures and signif-icant bioactivities in 2020.In this paper we review 271 valuable natural products,including terpenoids,steroids,flavonoids,phenylpropanoids,phenolics,nitrogen containing compounds and essential oil,etc.,isolated and identified from TCMs published in journals of Chinese Traditional and Herbal Drugs(Zhong Cao Yao)and Chinese Herbal Medicines(CHMs),and focus on their structures,source organisms,and rel-evant bioactivities,paying special attention to structural characteristics of novel compounds and newly revealed pharmacological properties of known compounds.It is worth noting that natural products with antitumor activity still constitute the primary object of research.Among the reported compounds,two new triterpenoids,i.e.,ursolic acid 3-O-β-cis-caffeate and mollugoside E,display remarkable cytotoxicity against PC-9 and HL-60 cell lines,respectively.Three known phenolic compounds,i.e.,pyoluteorin,4-hydroxy-3-methoxy cinnamaldehyde and 3,7-dimethoxy-5-hydroxy-1,4-phenanthrenequinone,exhibit significant cytotoxicity against multiple cell lines.Numerous studies on the free radical scavenging activ-ity of reported compounds are currently underway.In vitro,three known phenolic compounds,i.e.,3,4-O-dicaffeoylquinic acid methyl ester,3,4,5-O-tricaffeoylquinic acid methyl ester and arbutin,had more con-siderable antioxidant activities than vitamin C.The anti-inflammatory,anti-diabetic,hypolipidemic,neu-roprotective and antimicrobial activities of isolated compounds are also encouraging.The structural characteristics and bioactivities of TCM compounds highlighted here reflect the enormous progress of CHM research in 2020 and will play a positive role in the future drug discovery and development.According to pharmacophylogeny,the phylogenetic distribution of compounds with different natures and flavors can be explored,with view to better mining TCM resources.

Xiaojie Gu;Dacheng Hao;Peigen Xiao

Biotechnology Institute,School of Environment and Chemical Engineering,Dalian Jiaotong University,Dalian 116028,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China

中草药（英文版）

[1]Xiaojie Gu;Dacheng Hao;Peigen Xiao-.Research progress of Chinese herbal medicine compounds and their bioactivities:Fruitful 2020)[J].中草药（英文版）,2022(02):171-186

Fruitful,trove,chemodiversity,pharmacophylogeny,CHMs,mollugoside,pyoluteorin,phenanthrenequinone,tricaffeoylquinic,roprotective

Research,progress,Chinese,herbal,compounds,their,bioactivities,Traditional,medicines,TCMs,have,continued,treasure,study,versatility,has,always,been,important,content,There,amazing,discovery,research,natural,components,novel,structures,In,this,paper,we,review,valuable,products,including,steroids,flavonoids,phenylpropanoids,phenolics,nitrogen,containing,essential,oil,etc,isolated,identified,from,published,journals,Herbal,Drugs,Zhong,Cao,Yao,Medicines,focus,organisms,rel,evant,paying,special,attention,structural,characteristics,newly,revealed,pharmacological,properties,known,It,worth,noting,that,antitumor,activity,still,constitute,primary,object,Among,reported,two,triterpenoids,ursolic,acid,cis,caffeate,display,remarkable,cytotoxicity,against,HL,cell,lines,respectively,Three,hydroxy,cinnamaldehyde,dimethoxy,exhibit,significant,multiple,Numerous,studies,free,radical,scavenging,are,currently,underway,vitro,three,dicaffeoylquinic,methyl,ester,arbutin,had,more,siderable,antioxidant,than,vitamin,inflammatory,diabetic,hypolipidemic,neu,antimicrobial,also,encouraging,highlighted,reflect,enormous,will,positive,role,future,drug,development,According,phylogenetic,distribution,different,natures,flavors,explored,better,mining,resources

0.568013