典型文献
Chlospicenes A and B,cyclopropane cracked lindenane sesquiterpenoid dimers with anti-nonalcoholic steatohepatitis activity from Chloranthus henryi
文献摘要：
Guided by MS/MS molecular networks strategy,chlospicenes A and B(1 and 2),the first example of cy-clopropane moiety cracked lindenane sesquiterpene Michael addition dimers,along with their biogenetic analogues(3 and 4),were targetedly discovered from the roots of Chloranthus henryi.Their structures in-cluding absolute configurations were characterized by NMR,ECD and X-ray diffraction analysis.The plau-sible biogenic pathway speculation indicated that cyclopropylcarbinyl rearrangement may dominate the key crack of cyclopropane moiety.In addition,compounds 1 and 2 showed significant anti-nonalcoholic steatohepatitis(NASH)activity in free fatty acid(FFA)-induced HepG2 cells by decreasing intracellular lipid accumulation.
文献关键词：
中图分类号：
作者姓名：
Jixin Li;Zhirong Cui;Yongyi Li;Chunhua Han;Yanqiu Zhang;Pengfei Tang;Letian Cui;Hao Zhang;Jun Luo;Lingyi Kong
作者机构：
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China;School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China
文献出处：
引用格式：
[1]Jixin Li;Zhirong Cui;Yongyi Li;Chunhua Han;Yanqiu Zhang;Pengfei Tang;Letian Cui;Hao Zhang;Jun Luo;Lingyi Kong-.Chlospicenes A and B,cyclopropane cracked lindenane sesquiterpenoid dimers with anti-nonalcoholic steatohepatitis activity from Chloranthus henryi)[J].中国化学快报（英文版）,2022(09):4257-4260
A类：
Chlospicenes,cyclopropane,lindenane,chlospicenes,clopropane,biogenetic,targetedly,plau,cyclopropylcarbinyl
B类：
cracked,sesquiterpenoid,dimers,anti,nonalcoholic,steatohepatitis,activity,from,Chloranthus,henryi,Guided,by,molecular,networks,strategy,first,example,moiety,sesquiterpene,Michael,addition,along,their,analogues,were,discovered,roots,Their,structures,cluding,absolute,configurations,characterized,NMR,ECD,ray,diffraction,analysis,sible,biogenic,pathway,speculation,indicated,that,rearrangement,may,dominate,key,In,compounds,showed,significant,NASH,free,fatty,acid,FFA,induced,HepG2,cells,decreasing,intracellular,lipid,accumulation
AB值：
0.578836
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