典型文献
Thiocytochalasins A-D,four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1
文献摘要：
Four unprecedented sulfur-containing cytochalasans,thiocytochalasins A-D(1-4),were isolated from an endophytic fungus Phoma multirostrata XJ-2-1.Thiocytochalasins A(1)and B(2)feature a novel 5/6/14/5 tetracyclic scaffold,which are the first examples of cytochalasan containing a thiophene moiety.Thiocy-tochalasins C(3)and D(4)are epimeric cytochalasan homodimers formed via a thioether bridge.Their structures with absolute configurations were established by detailed analysis of the HRESIMS,NMR,and X-ray crystallography.The plausible biogenetic pathway of 1-4 was postulated.Compounds 3 and 4 ex-hibited significant cytotoxicity against CT26 cells with IC50 values of 0.85 and 0.76 μmol/L,respectively.
文献关键词：
中图分类号：
作者姓名：
Xiaogang Peng;Jinling Chang;Ying Gao;Fangfang Duan;Hanli Ruan
作者机构：
School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,Wuhan 430030,China
文献出处：
引用格式：
[1]Xiaogang Peng;Jinling Chang;Ying Gao;Fangfang Duan;Hanli Ruan-.Thiocytochalasins A-D,four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1)[J].中国化学快报（英文版）,2022(10):4572-4576
A类：
Thiocytochalasins,cytochalasans,multirostrata,thiocytochalasins,cytochalasan,Thiocy,tochalasins,epimeric,homodimers,thioether,biogenetic
B类：
four,sulfur,containing,from,endophytic,fungus,Phoma,XJ,Four,unprecedented,were,isolated,feature,novel,tetracyclic,scaffold,which,are,first,examples,thiophene,moiety,formed,via,bridge,Their,structures,absolute,configurations,established,by,detailed,analysis,HRESIMS,NMR,ray,crystallography,plausible,pathway,was,postulated,Compounds,hibited,significant,cytotoxicity,against,CT26,cells,IC50,values,respectively
AB值：
0.522512
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