典型文献
Camganoids A and B,two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao
文献摘要：
Objective:To isolate and identify the undescribed compounds from the fruits of Cinnamomum migao and evaluate its nitric oxide inhibition potential.Methods:The chromatographic techniques of silica gel,Sephadex,and HPLC were used for isolation and purification of the compounds,while HR-ESI-MS,1D NMR,2D NMR,ECD,and X-ray diffraction tech-niques were used to characterize and confirm the isolated compounds.Moreover,the anti-inflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAW264.7 cells stimulated by LPS.Results:Camganoid A(1),a novel sesquiterpene possessing an unprecedented skeleton,and camganoid B(2),containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton,were iso-lated and identified from the fruits of C migao.The absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism(ECD)calculations.Among these com-pounds,compound 1 exhibited potent inhibitory activity against the production of nitric oxide with ICso value of 4.59 μmol/L in RAW264.7 cells stimulated by LPS.Conclusion:The isolation of two new skeletons from the fruits part of C migao possessed unique skele-tons which have not been reported before.
文献关键词：
中图分类号：
作者姓名：
Yongzhen Xiao;Ishaq Muhammad;Xianpeng Ma;Huajun Yu;Shikai Yan;Xue Xiao;Huizi Jin
作者机构：
Department of Natural Product Chemistry.School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China;Guizhou Jingcheng Pharmaceutical Co.,Ltd.,Guiyang 550200,China;Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China;Institute of Chinese Medicinal Sciences,Guangdong Pharmaceutical University,Guangzhou 510006,China
文献出处：
引用格式：
[1]Yongzhen Xiao;Ishaq Muhammad;Xianpeng Ma;Huajun Yu;Shikai Yan;Xue Xiao;Huizi Jin-.Camganoids A and B,two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao)[J].中草药（英文版）,2022(04):638-642
A类：
Camganoids,migao,Camganoid,camganoid
B类：
two,new,sesquiterpenes,different,carbon,skeletons,isolated,from,fruits,Cinnamomum,Objective,To,identify,undescribed,compounds,evaluate,nitric,oxide,inhibition,potential,Methods,chromatographic,techniques,silica,gel,Sephadex,HPLC,were,used,isolation,purification,while,ESI,1D,NMR,2D,ECD,ray,diffraction,characterize,Moreover,anti,inflammatory,activity,was,carried,out,check,inhibitory,against,production,RAW264,cells,stimulated,by,LPS,Results,novel,possessing,unprecedented,containing,unique,eight,membered,moiety,identified,absolute,configurations,confirmed,single,crystal,electronic,circular,dichroism,calculations,Among,these,exhibited,ICso,value,Conclusion,part,possessed,which,have,not,been,reported,before
AB值：
0.480145
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