典型文献
Humulus japonicus extract alleviates oxidative stress and apoptosis in 6-hydroxydopamine-induced PC12 cells
文献摘要：
Objective: To explore the possible neuroprotective activities of Humulus japonicus extract against Parkinson's disease (PD) in a cellular model.Methods: PD was modeled in PC12 cells using 6-hydroxydopamine (6-OHDA). The cell activity, intracellular levels of reactive oxygen species (ROS), anti-oxidative and anti-apoptotic effects, and other related indicators and related signaling pathways were evaluated to elucidate the neuroprotective effects of Humulus japonicus extract. Results: Humulus japonicus extract exhibited anti-oxidative and anti-apoptotic effects in 6-OHDA-stimulated PC12 cells. It also reduced oxidative stress-induced ROS accumulation; upregulated antioxidant enzymes, such as glutathione, catalase, heme oxidase-1, and 8-oxguanine glycosylase 1; promoted cell survival by decreasing BAX and increasing Bcl-2 and sirtuin 1 expression via the MAPK and/or Nrf2 signaling pathways. Conclusions: Humulus japonicus extract has antioxidative and anti-apoptotic effects and could be developed as a promising candidate for preventing and treating oxidative stress-related neurodegenerative diseases.
文献关键词：
中图分类号：
作者姓名：
Feng Wang;Byoung Ok Cho;Jae Young Shin;Suping Hao;Seon Il Jang
作者机构：
Department of Health Management,Jeonju University,Jeonju 55069,Korea;Department of Life Sciences,Yuncheng University,Yuncheng,Shanxi Province 044000,PR China;Research Institute,Ato Q&A Co,LTD,Cheonjam-ro,Wansan-gu,Jeonju 55069,Korea;Institute of Health&Science,Jeonju University,Jeonju 55069,Korea
文献出处：
引用格式：
[1]Feng Wang;Byoung Ok Cho;Jae Young Shin;Suping Hao;Seon Il Jang-.Humulus japonicus extract alleviates oxidative stress and apoptosis in 6-hydroxydopamine-induced PC12 cells)[J].亚太热带生物医学杂志（英文版）,2022(05):197-206
A类：
oxguanine
B类：
Humulus,japonicus,extract,alleviates,stress,apoptosis,hydroxydopamine,induced,PC12,cells,Objective,To,explore,possible,neuroprotective,activities,against,Parkinson,Methods,was,modeled,using,OHDA,activity,intracellular,levels,reactive,oxygen,species,ROS,apoptotic,effects,other,related,indicators,signaling,pathways,were,evaluated,elucidate,Results,exhibited,stimulated,It,also,reduced,accumulation,upregulated,antioxidant,enzymes,such,glutathione,catalase,heme,oxidase,glycosylase,promoted,survival,by,decreasing,BAX,increasing,Bcl,sirtuin,expression,MAPK,Nrf2,Conclusions,has,antioxidative,could,be,developed,promising,candidate,preventing,treating,neurodegenerative,diseases
AB值：
0.550729
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
