典型文献
Three quinolizidine dimers from the seeds of Sophora alopecuroides and their hepatoprotective activities
文献摘要：
Sophoralines A-C,three novel[2+2]cycloaddition dimers of matrine-based alkaloids with an un-precedented 6/6/6/6/4/6/6/6/6 nonacyclic skeleton containing 11 stereogenic centers,were isolated from Sophora alopecuroides.Their structures were determined by spectroscopic methods,and the absolute con-figurations were further determined by single-crystal X-ray diffraction analysis for 1 and quantum chemi-cal calculations of electronic circular dichroism(ECD)spectra for 2 and 3.Moreover,1 exhibited excellent hepatoprotective activities in acetaminophen-induced liver injury in vitro and in vivo.
文献关键词：
中图分类号：
作者姓名：
Xiang Yuan;Jianshuang Jiang;Yanan Yang;Xu Zhang;Ziming Feng;Peicheng Zhang
作者机构：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China
文献出处：
引用格式：
[1]Xiang Yuan;Jianshuang Jiang;Yanan Yang;Xu Zhang;Ziming Feng;Peicheng Zhang-.Three quinolizidine dimers from the seeds of Sophora alopecuroides and their hepatoprotective activities)[J].中国化学快报（英文版）,2022(06):2923-2927
A类：
quinolizidine,Sophoralines,matrine,precedented,nonacyclic
B类：
Three,dimers,from,seeds,alopecuroides,their,hepatoprotective,activities,three,novel,2+2,cycloaddition,alkaloids,un,skeleton,containing,stereogenic,centers,were,isolated,Their,structures,determined,by,spectroscopic,methods,absolute,figurations,further,single,crystal,ray,diffraction,analysis,quantum,chemi,calculations,electronic,circular,dichroism,ECD,spectra,Moreover,exhibited,excellent,acetaminophen,induced,liver,injury,vitro,vivo
AB值：
0.625095
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