Nano-drug delivery strategies have been highlighted in cancer treatment,and much effort has been made in the optimization of bioavailability,biocompatibility,pharmacokinetics profiles,and in vivo distributions of anticancer nano-drug delivery systems.However,problems still exist in the delicate bal-ance between improved anticancer efficacy and reduced toxicity to normal tissues,and opportunities arise along with the development of smart stimuli-responsive delivery strategies.By on-demand responsiveness towards exogenous or endogenous stimulus,these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner.Meanwhile,the blossom of nanotechnology,material sciences,and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics,versatile functions,and modification possibil-ities.This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems.It may provide references for researchers in the fields of drug delivery,biomate-rials,and nanotechnology.

Xiaoyou Wang;Chong Li;Yiguang Wang;Huabing Chen;Xinxin Zhang;Cong Luo;Wenhu Zhou;Lili Li;Lesheng Teng;Haijun Yu;Jiancheng Wang

College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China;Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;School of Radiation Medicine and Protection,Soochow University,Suzhou 215123,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China;CAS Center for Excellence in Nanoscience,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing 100190,China;School of Life Sciences,Jilin University,Changchun 130012,China

药学学报（英文版）

[1]Xiaoyou Wang;Chong Li;Yiguang Wang;Huabing Chen;Xinxin Zhang;Cong Luo;Wenhu Zhou;Lili Li;Lesheng Teng;Haijun Yu;Jiancheng Wang-.Smart drug delivery systems for precise cancer therapy)[J].药学学报（英文版）,2022(11):4098-4121

biomate

Smart,drug,delivery,systems,precise,therapy,Nano,strategies,have,been,highlighted,treatment,much,effort,has,made,optimization,bioavailability,biocompatibility,pharmacokinetics,profiles,vivo,distributions,anticancer,However,problems,still,exist,delicate,bal,between,improved,efficacy,reduced,toxicity,normal,tissues,opportunities,arise,along,development,smart,stimuli,By,demand,responsiveness,towards,exogenous,endogenous,stimulus,these,hold,promise,advanced,tumor,specificity,well,controllable,release,behavior,spatial,temporal,manner,Meanwhile,blossom,nanotechnology,material,sciences,biomedical,shed,diverse,modern,characteristics,versatile,functions,modification,possibil,This,review,summarizes,current,progress,various,against,malignancies,introduces,representative,It,may,provide,references,researchers,fields,rials

0.611017