典型文献
Potential of ginsenoside Rh2 and its derivatives as anti-cancer agents
文献摘要：
As a steroid skeleton-based saponin,ginsenoside Rh2(G-Rh2)is one of the major bioactive ginsenosides from the plants of genus Panax L.Many studies have reported the notable pharmacological activities of G-Rh2 such as anticancer,antiinflam-matory,antiviral,antiallergic,antidiabetic,and anti-Alzheimer's activities.Numerous preclinical studies have demonstrated the great potential of G-Rh2 in the treatment of a wide range of carcinomatous diseases in vitro and in vivo.G-Rh2 is able to inhibit proliferation,induce apoptosis and cell cycle arrest,retard metastasis,promote differentiation,enhance chemotherapy and reverse multi-drug resist-ance against multiple tumor cells.The present review mainly summarizes the anticancer effects and related mechanisms of G-Rh2 in various models as well as the recent advances in G-Rh2 delivery systems and structural modification to ameliorate its anticancer activ-ity and pharmacokinetics characteristics.
文献关键词：
中图分类号：
作者姓名：
LI Keke;LI Zhongyu;Men Lei;LI Wei;GONG Xiaojie
作者机构：
Key Laboratory of Biotechnology and Bioresources Utilization,Ministry of Education,Dalian Minzu University,Dalian 116600,China;College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China
文献出处：
引用格式：
[1]LI Keke;LI Zhongyu;Men Lei;LI Wei;GONG Xiaojie-.Potential of ginsenoside Rh2 and its derivatives as anti-cancer agents)[J].中国天然药物,2022(12):881-901
A类：
antiinflam,antiallergic,carcinomatous
B类：
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AB值：
0.617344
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