典型文献
A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine
文献摘要：
Self-assembly is a powerful approach in molecular engineering for biomedical applications,in particu-lar for creating self-assembling prodrugs.Here,we report a self-assembling prodrug of the anticancer drug gemcitabine(Gem)based on amphiphilic dendrimer approach.The prodrug reported in this study demonstrates high drug loading(40％)and robust ability to self-assemble into small nanomicelles,which increase the metabolic stability of Gem and enable entry into cells via endocytosis,hence bypassing transport-mediated uptake.In addition,this prodrug nanosystem exhibited an effective pH-and enzyme-responsive release of Gem,resulting in enhanced anticancer activity and reduced toxicity.Harboring ad-vantageous features of both prodrug-and nanotechnology-based drug delivery,this self-assembling Gem prodrug nanosystem constitutes a promising anticancer candidate.This study also offers new perspectives of the amphiphilic dendrimer nanoplatforms for the development of self-assembling prodrugs.
文献关键词：
中图分类号：
作者姓名：
Mei Cong;Guangling Xu;Shaoyou Yang;Jing Zhang;Wenzheng Zhang;Dinesh Dhumal;Erik Laurini;Kaiyue Zhang;Yi Xia;Sabrina Pricl;Ling Peng;Weidong Zhao
作者机构：
School of Pharmacy,Xinxiang Medical University,Xinxiang 453003,China;Henan Key Laboratory of Immunology and Targeted Drugs,School of Laboratory Medicine,Xinxiang Medical University,Xinxiang 453003,China;Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine,School of Laboratory Medicine,Xinxiang Medical University,Xinxiang 453003,China;Aix-Marseille Université,CNRS,Center Interdisciplinaire de Nanoscience de Marseille,UMR 7325,Equipe Labellisé par La Ligue,Marseille 13288,France;Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,School of Pharmaceutical Sciences,Chongqing University,Chongqing 401331,China;Molecular Biology and Nanotechnology Laboratory,Department of Engineering and Architecture,University of Trieste,Trieste 34127,Italy;Department of General Biophysics,Faculty of Biology and Environmental Protection,University of Lodz,Lodz 90-236,Poland
文献出处：
引用格式：
[1]Mei Cong;Guangling Xu;Shaoyou Yang;Jing Zhang;Wenzheng Zhang;Dinesh Dhumal;Erik Laurini;Kaiyue Zhang;Yi Xia;Sabrina Pricl;Ling Peng;Weidong Zhao-.A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine)[J].中国化学快报（英文版）,2022(05):2481-2485
A类：
Harboring,vantageous
B类：
self,assembling,nanosystem,metabolic,stability,anticancer,activity,gemcitabine,Self,assembly,powerful,approach,molecular,engineering,biomedical,applications,particu,creating,prodrugs,Here,Gem,amphiphilic,dendrimer,reported,this,study,demonstrates,high,loading,robust,assemble,into,small,nanomicelles,which,increase,enable,entry,cells,via,endocytosis,hence,bypassing,transport,mediated,uptake,In,addition,exhibited,effective,enzyme,responsive,release,resulting,enhanced,reduced,toxicity,features,both,nanotechnology,delivery,constitutes,promising,candidate,This,also,offers,new,perspectives,nanoplatforms,development
AB值：
0.509069
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