典型文献
LNP-CDN:a novel nanomaterial for inflaming immune-cold malignant pleural effusion
文献摘要：
Malignant pleural effusion(MPE)is a pleural effusion caused by a primary pleural tumor or other malignant tumor that has metas-tasized to the pleura[1],and its presence usually indicates that the cancer has already spread or advanced.Patients with MPE have a poor prognosis,often presenting with respiratory distress and impaired quality of life.The median survival of patients with MPE ranges from three months to one year[2]with the worst prognosis for lung cancer,and with a relatively longer survival for gynecological tumors,probably due to the different sensitivity of the underlying tumors to treatment[3].Current treatment for MPE includes systemic chemotherapy,local or systemic immunotherapy,and palliative treatments,which have shown a modest improvement in survival in patients with MPE[4].How-ever,it is well recognized that the tumor microenvironment(TME)of MPE is strongly immunosuppressive,with an abundance of tumor-promoting myeloid immune cells and high levels of immunosuppressive cytokines that prevent the body's immune system from recognizing and eliminating cancer[5].Recently,Liu et al.[6]developed a liposomal nanoparticle loaded with cyclic dinucleotide(LNP-CDN),which transformed the"immune cold"MPE into an inflamed phenotype and promoted innate and adap-tive immune responses to achieve remarkable enhancement of anti-PD-L1 therapy(Fig.1).
文献关键词：
中图分类号：
作者姓名：
Qianglin Liu;Jie Mei;Chunying Chen
作者机构：
School of Medical and Life Sciences/Reproductive&Women-children Hospital,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Beijing 100190,China;School of Nanoscience and Technology,University of Chinese Academy of Sciences,Beijing 100049,China;The GBA National Institute for Nanotechnology Innovation,Guangzhou 510700,China
文献出处：
引用格式：
[1]Qianglin Liu;Jie Mei;Chunying Chen-.LNP-CDN:a novel nanomaterial for inflaming immune-cold malignant pleural effusion)[J].科学通报（英文版）,2022(18):1837-1839
A类：
inflaming,tasized
B类：
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AB值：
0.587156
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