典型文献
Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor
文献摘要：
The dense desmoplastic stroma and immunosuppressive microenvironment of pancreatic cancer hinder the penetration of drugs and induce a considerable resistance to conventional chemoradiotherapy.Although nanomedicine has recently shown attractive potential in cancer immunotherapy,it remains a great challenge to achieve efficient drug delivery and potent immune activation.Here,a stimuli-responsive nanosystem,comprising superparamagnetic iron oxide nanocrystals and nitric oxide(NO)donors,was developed for in-situ triggered catalytic cascade reaction to produce abundant free radicals and remodel the anti-tumor immunity.The nanosystem was activated in the tumor microenvironment to produce NO which dilated the tumor vasculature for efficient drug delivery,and the iron oxide nanocrystals catalyzed the reaction of NO to generate reactive oxygen-nitrogen species(RONS)with high cytotoxicity.Moreover,owing to the catalytic cascade reactions mediated by the nanosystem,the tumor associated macrophages(TAMs)were converted to a proinflammatory M1 phenotype and tumor infiltration of effector T cells was promoted to result in potent anti-tumor immunotherapy which could be readily monitored with magnetic resonance imaging(MRI).
文献关键词：
中图分类号：
作者姓名：
Gengjia Chen;Yujun Cai;Bo Li;Minzhao Lin;Xiaobin Wang;Zhiyong Wang;Xintao Shuai
作者机构：
Key Laboratory for Polymeric Composite&Functional Materials of Ministry of Education,School of Materials Science and Engineering,Sun Yat-sen University,Guangzhou 510275,China;Nanomedicine Research Center the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Minimally Invasive Interventional Radiology,Laboratory of Interventional Radiology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510275,China
文献出处：
引用格式：
[1]Gengjia Chen;Yujun Cai;Bo Li;Minzhao Lin;Xiaobin Wang;Zhiyong Wang;Xintao Shuai-.Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor)[J].中国科学:化学（英文版）,2022(07):1383-1400
A类：
remodel,RONS
B类：
Theranostic,nanosystem,mediating,cascade,catalytic,reactions,effective,immunotherapy,highly,immunosuppressive,poorly,penetrable,pancreatic,tumor,dense,desmoplastic,stroma,microenvironment,cancer,hinder,penetration,drugs,induce,considerable,resistance,conventional,chemoradiotherapy,Although,nanomedicine,has,recently,shown,attractive,potential,remains,great,challenge,achieve,efficient,delivery,immune,activation,Here,stimuli,responsive,comprising,superparamagnetic,oxide,nanocrystals,nitric,donors,was,developed,situ,triggered,produce,abundant,free,radicals,anti,immunity,activated,which,dilated,vasculature,catalyzed,generate,reactive,oxygen,nitrogen,species,cytotoxicity,Moreover,owing,mediated,by,associated,macrophages,TAMs,were,converted,proinflammatory,M1,phenotype,infiltration,effector,cells,promoted,result,could,be,readily,monitored,resonance,imaging
AB值：
0.603608
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