典型文献
Albumin-binding lipid-aptamer conjugates for cancer immunoimaging and immunotherapy
文献摘要：
Monitoring dynamic changes in tumor immune markers are essential for predicting the therapeutic responses of tumors to immunotherapy,as well as other traditional therapies,such as chemotherapy and radiotherapy.Here,we designed a lipid-aptamer conjugate by employing a C18 chain to modify an aptamer targeting programmed cell death-ligand 1(C18-apPDLl).The obtained C18-apPDLl could bind with serum albumin postintravenous injection to achieve prolonged blood circulation and enhanced in vivo stability without weakening its binding affinity toward PDL1.C18-apPDLl labeling with radionuclides,such as 99 mTc,could yield a nuclear imaging agent exhibiting much higher tumor-homing ability than bare aptamer.Notably,such radiolabeled C18-apPDLl could be utilized to visually monitor the dynamic changes in PDL1 expression postchemotherapy or radiotherapy within a few hours.Additionally,this C18-apPDLl could offer improved antitumor immune therapeutic responses,which are comparable with those of commercial anti-PDLl antibodies at the same weight dosage.Thus,this article presented promising lipid-modified aptamers for cancer immunoimaging and immunotherapy.
文献关键词：
中图分类号：
作者姓名：
Longlong Tian;Ming Shao;Yimou Gong;Yu Chao;Ting Wei;Kai Yang;Qian Chen;Zhuang Liu
作者机构：
Institute of Molecular Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Frontiers Science Center for Rare Isotopes,Lanzhou University,Lanzhou 730000,China;Institute of Functional Nano and Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou 215123,China;State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China
文献出处：
引用格式：
[1]Longlong Tian;Ming Shao;Yimou Gong;Yu Chao;Ting Wei;Kai Yang;Qian Chen;Zhuang Liu-.Albumin-binding lipid-aptamer conjugates for cancer immunoimaging and immunotherapy)[J].中国科学:化学（英文版）,2022(03):574-583
A类：
immunoimaging,apPDLl,postintravenous,postchemotherapy,PDLl
B类：
Albumin,binding,lipid,conjugates,cancer,immunotherapy,Monitoring,dynamic,changes,immune,markers,essential,predicting,therapeutic,responses,tumors,as,well,traditional,therapies,such,radiotherapy,Here,designed,by,employing,C18,chain,modify,targeting,programmed,cell,death,ligand,obtained,could,serum,albumin,injection,achieve,prolonged,blood,circulation,enhanced,vivo,stability,without,weakening,its,affinity,toward,PDL1,labeling,radionuclides,mTc,yield,nuclear,agent,exhibiting,much,higher,homing,than,bare,Notably,radiolabeled,utilized,visually,monitor,expression,within,few,hours,Additionally,this,offer,improved,antitumor,which,comparable,those,commercial,antibodies,same,weight,dosage,Thus,article,presented,promising,modified,aptamers
AB值：
0.550842
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