典型文献
Bio-inspired natural platelet hydrogels for wound healing
文献摘要：
Wound healing has invariably been a fundamental health concern,demanding manpower and materials and causing financial burdens.In this research,inspired by the hemostatic function of platelets,we pro-posed a novel bionic hydrogel by covalent amidation crosslinking natural platelet and alginate for wound healing.With the natural functional groups,the platelet-derived hydrogel exhibited outstanding biocom-patibility and blood compatibility.By changing the addition ratio of platelets to alginates,the mechanical properties of the achieved hydrogel were variable to cater to different wound environments.Furthermore,silver nanoparticles could be loaded into the void space of the hydrogel which endowed the composites with superior anti-infective properties.We have demonstrated that the bio-inspired pla-telet hydrogel could promote hemostasis of acute tissue damage,prevent bacterial proliferation,and pro-mote angiogenesis,collagen deposition,and granulation tissue formation in wound healing.These features signify the potential values of the bio-inspired platelet hydrogel in clinical applications.
文献关键词：
中图分类号：
作者姓名：
Yuanyuan Jiang;Jie Wang;Hui Zhang;Guopu Chen;Yuanjin Zhao
作者机构：
Children's Hospital of Nanjing Medical University,Nanjing 210008,China;College of Artificial Intelligence,Nanjing Agricultural University,Nanjing 210031,China;State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China;Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing University,Nanjing 210096,China
文献出处：
引用格式：
[1]Yuanyuan Jiang;Jie Wang;Hui Zhang;Guopu Chen;Yuanjin Zhao-.Bio-inspired natural platelet hydrogels for wound healing)[J].科学通报（英文版）,2022(17):1776-1784
A类：
amidation,alginates,cater,telet
B类：
Bio,inspired,natural,hydrogels,wound,healing,Wound,has,invariably,been,fundamental,health,concern,demanding,manpower,materials,causing,financial,burdens,In,this,research,by,hemostatic,platelets,posed,novel,bionic,covalent,crosslinking,With,functional,groups,derived,exhibited,outstanding,biocom,blood,compatibility,By,changing,addition,mechanical,properties,achieved,were,variable,different,environments,Furthermore,silver,nanoparticles,could,loaded,into,void,space,which,endowed,composites,superior,anti,infective,We,have,demonstrated,that,promote,hemostasis,acute,tissue,damage,prevent,bacterial,proliferation,angiogenesis,collagen,deposition,granulation,formation,These,features,signify,potential,values,clinical,applications
AB值：
0.590057
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