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A novel corneal adhesive based on functionally coupled PEG-lysozyme hydrogel for wound closure after surgical eye surgery
文献摘要：
Corneal wound closure for surgical eye surgeries or accidents is typically performed to prevent pathogens from the sterile intraocular environment and avoid potential postoperative complications.Tissue adhe-sives are increasingly employed for corneal wound closure with superior treatment efficiency and less adverse effects.In this study,we successfully develop a novel corneal adhesive based on functionally coupled PEG-lysozyme(PEG-LZ)hydrogels for wound closure after surgical eye surgeries.PEG-LZ hydro-gels have plenty of micropores and gradually decreased pore size with increasing concentration from 10％,15％to 20％(w/v),in which PEG-LZ(15％)represents the suitable pH value,gelation time and elastic mod-ulus.PEG-LZ hydrogels have no in vitro cytotoxicity and excellent ex vivo wound closure effectiveness in porcine eyes.The in vivo wound sealant in rabbit eyes by PEG-LZ hydrogels presents a superior thera-peutic effect compared with the conventional methods of stromal hydration and suture,in terms of the wound closure percent,mean corneal thickness,percent of wound gaping,and the Descemet membrane detachment.PEG-LZ hydrogels do not induce obvious histological pathology changes.The PEG-LZ corneal adhesive is considered as a tissue adhesive alternative for wound closure after surgical eye surgeries.
文献关键词：
中图分类号：
[1] 自动化技术、计算机技术（TP） / 计算技术、计算机技术（TP3） / 计算机的应用（TP39） / 信息处理(信息加工)（TP391）
[2] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）
[3] 医药、卫生（R） / 基础医学（R3） / 病理学（R36） / 病理过程（R364）
作者姓名：
Shaohua Zhang;Hang Zhou;Chang Huang;Jianguo Sun;Xue Qu;Yi Lu
作者机构：
Eye Institute and Department of Ophthalmology,NHC Key Laboratory of Myopia(Fudan University),Key Laboratory of Myopia,Chinese Academy of Medical Sciences,Shanghai Key Laboratory of Visual Impairment and Restoration,Eye&ENT Hospital,Fudan University,Shanghai 200031,China;Key Laboratory for Ultrafine Materials of Ministry of Education,School of Material Science and Engineering,East China University of Science and Technology,Shanghai 200237,China
文献出处：
中国化学快报（英文版）
引用格式：
[1]Shaohua Zhang;Hang Zhou;Chang Huang;Jianguo Sun;Xue Qu;Yi Lu-.A novel corneal adhesive based on functionally coupled PEG-lysozyme hydrogel for wound closure after surgical eye surgery)[J].中国化学快报（英文版）,2022(09):4321-4325
A类：
gaping
B类：
novel,corneal,adhesive,functionally,coupled,PEG,lysozyme,wound,closure,after,surgical,surgery,Corneal,surgeries,accidents,typically,performed,prevent,pathogens,from,sterile,intraocular,environment,avoid,potential,postoperative,complications,Tissue,sives,increasingly,employed,superior,treatment,efficiency,less,adverse,effects,In,this,study,we,successfully,develop,LZ,hydrogels,have,plenty,micropores,gradually,decreased,size,concentration,which,represents,suitable,value,gelation,elastic,mod,ulus,vitro,cytotoxicity,excellent,vivo,effectiveness,porcine,eyes,sealant,rabbit,by,thera,peutic,compared,conventional,methods,stromal,hydration,suture,terms,percent,mean,thickness,Descemet,membrane,detachment,do,not,induce,obvious,histological,pathology,changes,considered,tissue,alternative
AB值：
0.500235
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