典型文献
Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair
文献摘要：
Diabetic wounds lead to a decrease in quality of life and an increase in mortality.Current treatment strategies include preventing bacterial adhesion while improving microcirculation.As a new type of wound dressing that imitates natural skin,hydrogel has gradually emerged with its excellent properties.However,existing hydrogels rarely achieve satisfactory results in promoting wound repair and antibacte-rial simultaneously.In this case,we prepared methacrylic anhydride chemically modified hyaluronic acid as a hydrogel matrix,added polyhexamethylene biguanide as an antibacterial component,and loaded sodium alginate/salidroside composite microspheres which could sustainably release salidroside and thus promote angiogenesis.Hybrid hydrogel(HAMA/PHMB-Ms)was synthesized via photocrosslinking,and its chemical structure,particle size distribution and microstructure were characterized.The satisfactory an-tibacterial properties of the HAMA/PHMB(15％)-Ms hydrogel were studied in vitro,and its antibacterial rates against E.coli and S.aureus were 97.85％and 98.56％,respectively.In addition,after demonstrating its good biocompatibility,we verified that the HAMA/PHMB-Ms hydrogel has increased granulation tissue formation,more collagen deposition,more subcutaneous capillary formation,and better wound healing than blank control,HAMA and HAMA/PHMB hydrogel on the back wound model of diabetic mice.The results confirmed that HAMA/PHMB-Ms hydrogel was a promising material for the treatment of the dia-betic wounds.
文献关键词：
中图分类号：
作者姓名：
Yike Li;Huiyu Zheng;Yaxian Liang;Ming Xuan;Guiting Liu;Huixu Xie
作者机构：
State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610041,China
文献出处：
引用格式：
[1]Yike Li;Huiyu Zheng;Yaxian Liang;Ming Xuan;Guiting Liu;Huixu Xie-.Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair)[J].中国化学快报（英文版）,2022(12):5030-5034
A类：
polyhexamethylene,biguanide,antibacte,photocrosslinking,tibacterial
B类：
Hyaluronic,acid,methacrylic,anhydride,hybrid,antibacterial,proangiogenic,functions,diabetic,repair,Diabetic,wounds,lead,decrease,quality,life,mortality,Current,treatment,strategies,include,preventing,adhesion,while,improving,microcirculation,new,type,dressing,that,imitates,natural,skin,has,gradually,emerged,its,excellent,properties,However,existing,hydrogels,rarely,achieve,satisfactory,results,promoting,simultaneously,In,this,case,prepared,chemically,modified,hyaluronic,matrix,added,component,loaded,sodium,alginate,salidroside,composite,microspheres,which,could,sustainably,release,thus,promote,angiogenesis,Hybrid,HAMA,PHMB,Ms,was,synthesized,via,particle,distribution,microstructure,were,characterized,studied,vitro,rates,against,coli,aureus,respectively,addition,after,demonstrating,good,biocompatibility,verified,increased,granulation,tissue,formation,more,collagen,deposition,subcutaneous,capillary,better,healing,than,blank,control,back,model,mice,confirmed,promising,material
AB值：
0.542156
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
