典型文献
Nanoplateletsomes for rapid hemostasis performance
文献摘要：
Uncontrollable hemorrhage remains staple trouble in surgical procedures and a leading cause after major trauma.The bleeding issue may trigger various pathologic scenarios that can lead to tissue morbidities and mortalities,and currently available on-site hemostatic agents are confined to a narrow therapeutic index and may carry the risk of immunogenicity.Inspired by the crucial role of platelets in the process of thrombus,a platelet-mimetic plateletsome with wound targeting and blood coagulation properties is developed for hemorrhage control.Plateletsome is formulated by integrating platelet membranes with functionalized synthetic liposomes and exhibits superior wound targeting and effective hemostasis prop-erties.It presents less blood loss and shorter hemostasis time than the platelet membrane vehicles or the conventional liposomes in the mouse tail transection model.The strong homing of the biomimetic plateletsome to the thrombus was also confirmed,demonstrating the potential of this engineered cell membrane vesicle as a biomimetic hemostat for bleeding treatment.
文献关键词：
中图分类号：
作者姓名：
Honglan Wang;Yuefei Zhu;Longlong Zhang;Huiwen Liu;Chunying Liu;Bo Zhang;Yanan Song;Yu Hu;Zhiqing Pang
作者机构：
Key Laboratory of Smart Drug Delivery,Ministry of Education,School of Pharmacy,Fudan University,Shanghai 201203,China;Institute of Hematology,Union Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430022,China;Department of Biomedical Engineering,Columbia University,New York,NY 10027,United States
文献出处：
引用格式：
[1]Honglan Wang;Yuefei Zhu;Longlong Zhang;Huiwen Liu;Chunying Liu;Bo Zhang;Yanan Song;Yu Hu;Zhiqing Pang-.Nanoplateletsomes for rapid hemostasis performance)[J].中国化学快报（英文版）,2022(06):2937-2941
A类：
Nanoplateletsomes,Uncontrollable,plateletsome,Plateletsome,hemostat
B类：
rapid,hemostasis,performance,hemorrhage,remains,staple,trouble,surgical,procedures,leading,cause,after,major,trauma,bleeding,may,trigger,various,pathologic,scenarios,that,can,tissue,morbidities,mortalities,currently,available,site,hemostatic,agents,are,confined,narrow,therapeutic,carry,risk,immunogenicity,Inspired,by,crucial,role,process,thrombus,wound,targeting,blood,coagulation,properties,developed,formulated,integrating,membranes,functionalized,synthetic,liposomes,exhibits,superior,effective,It,presents,less,loss,shorter,than,vehicles,conventional,mouse,tail,transection,model,strong,homing,biomimetic,was,also,confirmed,demonstrating,potential,this,engineered,cell,vesicle,treatment
AB值：
0.59456
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
