典型文献
A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan
文献摘要：
The ability to protect cellular components in the face of deleterious conditions, such as exposure to chemical poisons, damaging radiation, or excessive heat, is crucial to organismal viability. Several compartmentalized stress response pathways have evolved to mitigate damage and increase cellular fitness in such environments, including the unfolded protein response of the endoplasmic reticulum (UPRER). The UPRER serves a critical protective role by promoting proteome integrity and lipid homeostasis while preventing the accumulation of damaged proteins and protein aggregates. The ability to mount an effective UPRER is a key determinant of organismal lifespan and stress resistance, however, as with other stress responses, it has been shown to decline markedly during the aging process. This leaves the proteomes of aged animals susceptible to dysregulation and dysfunction, which in turn further contributes to an accelerated aging process, development of age-associated pathology, and proteotoxicity (Higuchi-Sanabria et al., 2018).
文献关键词：
中图分类号：
作者姓名：
Stefan Homentcovschi
作者机构：
Department of Molecular&Cellular Biology,University of California,Berkeley,CA,USA
文献出处：
引用格式：
[1]Stefan Homentcovschi-.A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan)[J].中国神经再生研究（英文版）,2022(02):309-310
A类：
ambrosia,UPRER,proteotoxicity,Sanabria
B类：
neuron,autonomous,unfolded,endoplasmic,reticulum,promotes,lifespan,cellular,components,face,deleterious,conditions,such,exposure,chemical,poisons,damaging,radiation,excessive,heat,crucial,organismal,viability,Several,compartmentalized,stress,pathways,have,evolved,mitigate,increase,fitness,environments,including,serves,critical,protective,role,by,promoting,integrity,lipid,homeostasis,while,preventing,accumulation,damaged,proteins,aggregates,mount,effective,key,determinant,resistance,however,other,responses,has,been,shown,decline,markedly,during,process,This,leaves,proteomes,animals,susceptible,dysregulation,dysfunction,which,turn,further,contributes,accelerated,development,associated,pathology,Higuchi
AB值：
0.585446
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
