典型文献
Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
文献摘要：
Dear Editor,
The severe fever with thrombocytopenia syndrome virus(SFTSV)is an emerging tick-borne pathogen belonging to the genus Bandavirus,family Phenuiviridae,which causes high fatality rates ranging from 12％to 30％(Kim et al.,2013).In the absence of efficacious drugs and vac-cines,therapies for SFTS are performed mostly according to the clinical manifestations accompanied by supportive treatment.The SFTSV poly-merase protein(SFTSV-L),encoded by its L segment,plays a critical role in genomic replication and transcription.Similar to other single negative-sense RNA viruses(sNSRVs),such as the influenza A virus(FluA)and the La Crosse virus(LASV),the SFTSV-L can be divided into three main functional regions,with the RNA-dependent RNA polymerase(RdRp)region flanked by the endonuclease region at the N-terminus and the cap-binding functional region at the C-terminus(Sanchez and de la Torre,2005;Pflug et al.,2014;Vogel et al.,2020a;Wang et al.,2020).
文献关键词：
中图分类号：
作者姓名：
Zhiyun Yin;Fuli Ren;Min Zhou;Shengyao Chen;Yali Deng;Sijing Hu;Fei Deng;Shu Shen;Junming Shi
作者机构：
National Virus Resource Center,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China;Academic Affairs Office of Cangzhou Jiaotong University,Cangzhou,061199,China;Center for Translational Medicine,Jinyintan Hospital,Wuhan,430023,China
文献出处：
引用格式：
[1]Zhiyun Yin;Fuli Ren;Min Zhou;Shengyao Chen;Yali Deng;Sijing Hu;Fei Deng;Shu Shen;Junming Shi-.Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism)[J].中国病毒学,2022(06):946-949
A类：
Bandavirus,Phenuiviridae,sNSRVs,Pflug
B类：
Roles,functional,domains,conserved,residues,severe,fever,thrombocytopenia,syndrome,protein,provide,insights,into,viral,transcription,replication,mechanism,Dear,Editor,
The,SFTSV,emerging,tick,borne,pathogen,belonging,genus,family,which,causes,high,fatality,rates,ranging,from,Kim,et,In,absence,efficacious,drugs,vac,cines,therapies,are,performed,mostly,according,clinical,manifestations,accompanied,by,supportive,treatment,encoded,its,segment,plays,critical,role,genomic,Similar,other,single,negative,sense,viruses,such,influenza,FluA,La,Crosse,LASV,can,divided,three,regions,dependent,polymerase,RdRp,flanked,endonuclease,terminus,cap,binding,Sanchez,Torre,Vogel,2020a,Wang
AB值：
0.61143
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
