典型文献
Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system
文献摘要：
A mixed drug self-delivery system(DSDS)with high drug content(＞50％)was developed to regulate pH-triggered drug release,based on two doxorubicin(DOX)-DOX dimmers:D-DOXADH and D-DOXcar con-jugated with acid-labile dynamic covalent bonds(hydrazone and carbamate,respectively)and stabilized with PEGylated D-DOXADH(D-DOXADH-PEG).Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between them,pH-triggered drug release could be easily regulated by adjusting the feeding ratios of the two DOX-DOX dimers in the mixed DSDS.Similar in vitro cellular toxicity was achieved with the mixed DSDS nanoparticles prepared with different feeding ratios.The mixed DSDS nanoparticles had a similar DOX content and diameter but different drug releasing rates.The MTT assays revealed that a high anti-tumor efficacy could be achieved with the slow-release mixed DSDS nanoparticles.
文献关键词：
中图分类号：
作者姓名：
Jiagen Li;Xinming Li;Pengwei Xie;Peng Liu
作者机构：
State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou,730000,China
文献出处：
引用格式：
[1]Jiagen Li;Xinming Li;Pengwei Xie;Peng Liu-.Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system)[J].药物分析学报（英文）,2022(01):122-128
A类：
DSDS,dimmers,DOXADH,DOXcar
B类：
Regulation,drug,release,performance,using,mixed,doxorubicin,nanoparticles,triggered,self,delivery,system,high,content,was,developed,two,jugated,acid,labile,dynamic,bonds,hydrazone,carbamate,respectively,stabilized,PEGylated,Owing,different,stability,dimers,noncovalent,interaction,between,them,could,easily,regulated,by,adjusting,feeding,ratios,Similar,vitro,cellular,toxicity,achieved,prepared,had,similar,diameter,but,releasing,rates,MTT,assays,revealed,that,anti,tumor,efficacy,slow
AB值：
0.417753
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
