典型文献
A microenvironment sensitive pillar[5]arene-based fluorescent probe for cell imaging and drug delivery
文献摘要：
Dansylamide(DNSA)is a typical ICT probe that has a favorable serum albumin sensitivity.Inspired by this,we designed a microenvironment sensitive fluorescent probe 4C-G through introducing DNSA into pillar[5]arene.Unlike DNSA,4C-G displayed differentiated sensitivity to multiple proteins,which was ben-efit from pillar[5]arene assisted the probe to form complexes with proteins.4C-G could not only be ap-plied in imaging of HepG2,but also act as a favorable drug carrier for regorafenib(REG)encapsulation.The 4C-G-REG complex would aggregate into high drug-loading fluorescent nanoparticles in a physiolog-ical environment(pH 7.4).Such nanoparticles exhibited pH-triggered enrichment ability,which rapidly enriched REG in the acidic environment(pH 6.0).Furthermore,the complexation between 4C-G and REG maintained the imaging property of the probe and the excellent anticancer activity of the drug on HepG2.
文献关键词：
中图分类号：
作者姓名：
Qing Wang;Jingwen Fan;Xiaoyan Bian;Hang Yao;Xiaohui Yuan;Ying Han;Chaoguo Yan
作者机构：
School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China
文献出处：
引用格式：
[1]Qing Wang;Jingwen Fan;Xiaoyan Bian;Hang Yao;Xiaohui Yuan;Ying Han;Chaoguo Yan-.A microenvironment sensitive pillar[5]arene-based fluorescent probe for cell imaging and drug delivery)[J].中国化学快报（英文版）,2022(04):1979-1982
A类：
Dansylamide,DNSA,efit,regorafenib
B类：
microenvironment,sensitive,pillar,arene,fluorescent,probe,imaging,drug,delivery,typical,ICT,that,has,favorable,serum,albumin,sensitivity,Inspired,by,this,designed,4C,through,introducing,into,Unlike,displayed,differentiated,multiple,proteins,which,was,ben,from,assisted,form,complexes,could,not,only,plied,HepG2,but,also,carrier,REG,encapsulation,would,aggregate,high,loading,nanoparticles,physiolog,Such,exhibited,triggered,enrichment,ability,rapidly,enriched,acidic,Furthermore,complexation,between,maintained,property,excellent,anticancer,activity
AB值：
0.504629
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