典型文献
Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth
文献摘要：
Worldwide, more than 40 million people are afflicted with Alzheimer's disease (AD) (Esquerda-Canals et al., 2017). AD is a devastating neurodegenerative disroder characterized by progressive decline in cognitive abilities. A hallmark of AD and other neurodegenerative disorders in humans is the aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions (Iadanza et al., 2018). In AD, following a series of proteolytic cleavage events amyloid precursor proteins give rise to Aβ monomers, which, in turn, assemble into soluble amyloid oligomers (AOs) that ultimately become insoluble mature amyloid fibrils enriched with highly ordered cross β-sheet structures. This entire process is termed as amyloidogenesis (Chen et al., 2017).
文献关键词：
中图分类号：
作者姓名：
Zijian Tang
作者机构：
Mouse Cancer Genetics Program,Center forCancer Research,National Cancer Institute,Frederick,MD,USA
文献出处：
引用格式：
[1]Zijian Tang-.Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth)[J].中国神经再生研究（英文版）,2022(03):559-560
A类：
Esquerda,Canals,disroder,Iadanza,AOs,amyloidogenesis
B类：
Heat,shock,direct,anti,connecting,neurodegeneration,uncontrolled,growth,Worldwide,more,than,million,people,are,afflicted,Alzheimer,disease,AD,devastating,neurodegenerative,characterized,by,progressive,decline,cognitive,abilities,hallmark,other,disorders,humans,aggregation,proteins,into,fibrils,their,deposition,plaques,intracellular,inclusions,In,following,series,proteolytic,cleavage,events,precursor,give,rise,monomers,which,turn,assemble,oligomers,that,ultimately,become,insoluble,mature,enriched,highly,ordered,cross,sheet,structures,This,entire,process,termed,Chen
AB值：
0.633662
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
