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典型文献
Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders
文献摘要:
Dear Editor, Protein amyloid aggregation is a histological hallmark of neurodegenerative diseases(NDs).1,2 In synucleinopathies includ-ing Parkinson's disease(PD),Parkinson's disease dementia(PDD),dementia with Lewy body and multiple system atrophy,α-synuclein(α-syn)is commonly characterized to form amyloid aggregates presenting distinct pathological activities in diseased brains.3,4 Structural characterization of a-syn amyloid fibrils formed in different diseases could provide mechanistic under-standing of heterogeneous a-syn pathologies.
文献关键词:
作者姓名:
Yun Fan;Qinyue Zhao;Wencheng Xia;Youqi Tao;Wenbo Yu;Mingjia Chen;Yiqi Liu;Jue Zhao;Yan Shen;Yunpeng Sun;Chenfang Si;Shenqing Zhang;Yaoyang Zhang;Wensheng Li;Cong Liu;Jian Wang;Dan Li
作者机构:
Department of Neurology and National Research Center for Aging and Medicine&National Center for Neurological Disorders,State Key Laboratory of Medical Neurobiology,Huashan Hospital,Fudan University,Shanghai,China;Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai,China;Bio-X-Renji Hospital Research Center,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,China;University of Chinese Academy of Sciences,Beijing,China;Department of Anatomy and Histoembryology,School of Basic Medical Sciences,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai,China;Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China
引用格式:
[1]Yun Fan;Qinyue Zhao;Wencheng Xia;Youqi Tao;Wenbo Yu;Mingjia Chen;Yiqi Liu;Jue Zhao;Yan Shen;Yunpeng Sun;Chenfang Si;Shenqing Zhang;Yaoyang Zhang;Wensheng Li;Cong Liu;Jian Wang;Dan Li-.Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders)[J].细胞研究(英文版),2022(06):585-588
A类:
TMEM106B, Protein
B类:
Generic,amyloid,fibrillation,patient,Parkinson,dementia,normal,elders,Dear,Editor,aggregation,histological,hallmark,neurodegenerative,diseases,NDs,In,synucleinopathies,includ,PDD,Lewy,body,multiple,system,atrophy,commonly,characterized,aggregates,presenting,distinct,pathological,activities,diseased,brains,Structural,characterization,fibrils,formed,different,could,provide,mechanistic,under,standing,heterogeneous,pathologies
AB值:
0.658727
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