典型文献
MEF2C ameliorates learning,memory,and molecular pathological changes in Alzheimer's disease in vivo and in vitro
文献摘要：
Myocyte enhancer factor 2C(MEF2C)is highly expressed in the nervous system,and regulates neuro-development,synaptic plasticity,and inflammation.However,its mechanism in Alzheimer's disease(AD)is underestimated.In this study,the role and mechanism of MEF2C were investigated in the brain tissue specimens from patients with AD,APPswe/PSEN1dE9 double transgenic(APP/PS1_DT)mice,and SH-SY5Y cells treated with β-amyloid peptide(Aβ).The results indicated that the expression of MEF2C is significantly reduced,and the expression of MEF2C/Aβ in different parts of brain is negatively correlated in patients with AD.Knockdown of MEF2C promotes cell apoptosis and the level of β-amyloid precursor protein cleaving enzyme 1(BACE)but reduces BACE2 expression.In addition,knockdown of Mef2c enhances the generation and aggregation of Aβ in the cortex of APP/PS1_DT mice,reduces the expression of synaptic proteins,exacerbates the ability of learning and memory of APP/PS1_DT mice,damages the structure of mitochondria,increases the oxidative stress(OS)level,and inhibits the expression levels of members of the Nrf2-ARE signal pathway.In summary,inhibition of MEF2C exacerbates the toxic effect of Aβ in vivo and in vitro,damages synaptic plasticity,reduces the ability of learning and memory of APP/PS1 mice,and increases the level of OS via the Nrf2-ARE signal pathway.
文献关键词：
中图分类号：
作者姓名：
Jiamou Ren;Shuli Zhang;Xiaoling Wang;Yuxin Deng;Yi Zhao;Yan Xiao;Jian Liu;Liangzhao Chu;Xiaolan Qi
作者机构：
Key Laboratory of Endemic and Ethnic Diseases,Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou Province,Guizhou Medical University,Guiyang 550004,China;Department of Laboratory Medicine,the 4th People's Hospital of Guiyang,Guiyang 550004,China;Chinese People's Liberation Army,Secret Service Center Sanatorium of Xiamen,Xiamen 361000,China;Department of Neurosurgery,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Translational Medicine Research Center,Guizhou Medical University,Guiyang 550004,China
文献出处：
引用格式：
[1]Jiamou Ren;Shuli Zhang;Xiaoling Wang;Yuxin Deng;Yi Zhao;Yan Xiao;Jian Liu;Liangzhao Chu;Xiaolan Qi-.MEF2C ameliorates learning,memory,and molecular pathological changes in Alzheimer's disease in vivo and in vitro)[J].生物化学与生物物理学报（英文版）,2022(01):77-90
A类：
Myocyte,PSEN1dE9,BACE2,Mef2c
B类：
MEF2C,ameliorates,learning,memory,molecular,pathological,changes,Alzheimer,disease,vivo,vitro,enhancer,highly,expressed,nervous,system,regulates,neuro,development,synaptic,plasticity,inflammation,However,mechanism,AD,underestimated,In,this,study,role,were,investigated,brain,tissue,specimens,from,patients,APPswe,double,transgenic,PS1,DT,mice,SH,SY5Y,cells,treated,amyloid,peptide,results,indicated,that,expression,significantly,reduced,different,parts,negatively,correlated,Knockdown,promotes,apoptosis,precursor,cleaving,enzyme,but,reduces,addition,knockdown,enhances,generation,aggregation,cortex,proteins,exacerbates,ability,damages,structure,mitochondria,increases,oxidative,stress,OS,inhibits,levels,members,Nrf2,ARE,signal,pathway,summary,inhibition,toxic,effect,via
AB值：
0.49051
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
