典型文献
Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused on β-amyloid peptide
文献摘要：
Alzheimer's disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory impairment.Many lines of evidence indicate that excessive β-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal death.AD has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of challenges.To overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of AD.EGCG is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in AD.This review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ regulation.Furthermore,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.
文献关键词：
中图分类号：
作者姓名：
Kumju Youn;Chi-Tang Ho;Mira Jun
作者机构：
Department of Food Science and Nutrition,Dong-A University,Busan 49315,Korea;Department of Food Science,Rutgers University,NJ 08901,USA;Department of Health Sciences,The graduate School of Dong-A University,Busan 49315,Korea
文献出处：
引用格式：
[1]Kumju Youn;Chi-Tang Ho;Mira Jun-.Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused on β-amyloid peptide)[J].食品科学与人类健康（英文）,2022(03):483-493
A类：
Multifaceted
B类：
neuroprotective,effects,epigallocatechin,gallate,EGCG,Alzheimer,disease,overview,clinical,studies,focused,amyloid,peptide,AD,most,common,neurodegenerative,characterized,by,cognitive,decline,memory,impairment,Many,lines,evidence,indicate,that,excessive,generation,aggregation,play,pivotal,roles,initiation,leading,various,biochemical,alteration,including,oxidative,damage,mitochondrial,dysfunction,neuroinflammation,signaling,pathway,finally,resulting,neuronal,death,has,complex,pathogenic,mechanism,single,target,approach,anti,strategy,thus,full,challenges,To,overcome,these,limitations,present,study,review,one,multiple,compounds,prevention,treatment,main,bioactive,polyphenol,green,tea,been,reported,exert,potent,properties,wide,array,both,cellular,animal,models,This,demonstrated,efficacies,focusing,involvement,evoked,its,regulation,Furthermore,understand,action,brain,permeability,blood,barrier,was,also,discussed
AB值：
0.681662
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