典型文献
Mechanisms of Polycomb group protein function in cancer
文献摘要：
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-like phenotype characterized by uncontrolled growth.Polycomb Group(PcG)proteins are members of multiprotein complexes that are highly conserved throughout evolution.Historically,they have been described as essential for maintaining epigenetic cellular memory by locking homeotic genes in a transcriptionally repressed state.What was initially thought to be a function restricted to a few target genes,subsequently turned out to be of much broader relevance,since the main role of PcG complexes is to ensure a dynamically choregraphed spatio-temporal regulation of their numerous target genes during development.Their ability to modify chromatin landscapes and refine the expression of master genes controlling major switches in cellular decisions under physiological conditions is often misregulated in tumors.Surprisingly,their functional implication in the initiation and progression of cancer may be either dependent on Polycomb complexes,or specific for a subunit that acts independently of other PcG members.In this review,we describe how misregulated Polycomb proteins play a pleiotropic role in cancer by altering a broad spectrum of biological processes such as the proliferation-differentiation balance,metabolism and the immune response,all of which are crucial in tumor progression.We also illustrate how interfering with PcG functions can provide a powerful strategy to counter tumor progression.
文献关键词：
中图分类号：
作者姓名：
Victoria Parreno;Anne-Marie Martinez;Giacomo Cavalli
作者机构：
Institute of Human Genetics,UMR 9002,CNRS-University of Montpellier,Montpellier,France
文献出处：
引用格式：
[1]Victoria Parreno;Anne-Marie Martinez;Giacomo Cavalli-.Mechanisms of Polycomb group protein function in cancer)[J].细胞研究（英文版）,2022(03):231-253
A类：
PcG,choregraphed,misregulated
B类：
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AB值：
0.638283
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