典型文献
Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-amyloid deposition and brain atrophy
文献摘要：
Background::Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease (AD). However, there is a lack of direct evidence indicating whether hypoperfusion causes or aggravates AD pathology. We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology in humans.Methods::We enrolled a group of cognitively normal patients (median age: 64 years) with unilateral chronic cerebral hypoperfusion. Regions of interest with the most pronounced hypoperfusion changes were chosen in the hypoperfused region and were then mirrored in the contralateral hemisphere to create a control region with normal perfusion.
11C-Pittsburgh compound-positron emission tomography standard uptake ratios and brain atrophy indices were calculated from the computed tomography images of each patient.
Results::The median age of the 10 participants, consisting of 4 males and 6 females, was 64 years (47-76 years). We found that there were no differences in standard uptake ratios of the cortex (volume of interest [VOI]:
P = 0.721, region of interest [ROI]:
P = 0.241) and grey/white ratio (VOI:
P = 0.333, ROI:
P = 0.445) and brain atrophy indices (Bicaudate, Bifrontal, Evans, Cella, Cella media, and Ventricular index,
P > 0.05) between the hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion.
Conclusion::Our findings suggest that chronic hypoperfusion due to large vessel stenosis may not directly induce cerebral β-amyloid deposition and neurodegeneration in humans.
文献关键词：
Cerebral hypoperfusion;β-amyloid;Brain atrophy;Alzheimer disease
中图分类号：
作者姓名：
Fan Dongyu;Li Huiyun;Chen Dongwan;Chen Yang;Yi Xu;Yang Heng;Shi Qianqian;Jiao Fangyang;Tang Yi;Li Qiming;Wang Fangyang;Wang Shunan;Jin Rongbing;Zeng Fan;Wang Yanjiang
作者机构：
Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China;Institute of Brain and Intelligence, Third Military Medical University, Chongqing, 400038, China;Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China;Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Tibet 857012, China;Department of Nuclear Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China;Department of Radiology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China
文献出处：
引用格式：
[1]Fan Dongyu;Li Huiyun;Chen Dongwan;Chen Yang;Yi Xu;Yang Heng;Shi Qianqian;Jiao Fangyang;Tang Yi;Li Qiming;Wang Fangyang;Wang Shunan;Jin Rongbing;Zeng Fan;Wang Yanjiang-.Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-amyloid deposition and brain atrophy)[J].中华医学杂志（英文版）,2022(05):591-597
A类：
cognitively,hypoperfused,Bicaudate,Bifrontal,Cella
B类：
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AB值：
0.480434
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