典型文献
Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality
文献摘要：
Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is characterized by extracellular amyloid beta (Aβ) plaques, neurofibrillary tangles com-posed of hyperphosphorylated tau, neuronal death, synapse loss, and brain atrophy. Many therapies have been tested to improve or at least effectively modify the course of AD. Meaningful data indicate that the transplantation of stem cells can alleviate neuropathology and significantly ameliorate cognitive deficits in animal models with Alzheimer's disease. Transplanted stem cells have shown their inherent advantages in improving cognitive impairment and memory dysfunction, although certain weak-nesses or limitations need to be overcome. This review recapitulates rodent models for AD, the therapeutic efficacy of stem cells, influencing factors, and the underlying mechanisms behind these changes. Stem cell therapy provides perspective and chal-lenges for its clinical application in the future.
文献关键词：
中图分类号：
作者姓名：
Chuan Qin;Kewei Wang;Ling Zhang;Lin Bai
作者机构：
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences (CAMS),Comparative Medicine Center,Peking Union Medical College(PUMC), NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Human Diseases Animal Model, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing,Beijing,China
文献出处：
引用格式：
[1]Chuan Qin;Kewei Wang;Ling Zhang;Lin Bai-.Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality)[J].动物模型与实验医学（英文）,2022(01):15-26
A类：
Transplanted,recapitulates
B类：
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AB值：
0.702168
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