典型文献
Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging
文献摘要：
INTRODUCTION
Bone is a dynamic organ that consists of inorganic minerals, organic proteins, cells, lipids, and water and serves essential mechanical and homeostatic functions.1–2 However, with aging, the relative proportions of the components change over time. With the deterioration of bony microarchitecture,2 a rise in adiposity accompanies the reduction in trabecular bone volume.3 As early as age 30, the gradual bone mass reduction may initiate, and dynamic functions of bone become impaired. Bone fragility fracture and delayed healing significantly affect the well being of aging population.4 In addition, an imbalance in bone homeostasis and bone-to-fat ratio accumulates with the advance in age, denoting aging as a critical risk factor for developing metabolic disorders such as osteoporosis.
文献关键词：
中图分类号：
作者姓名：
Peng Deng;Insoon Chang;Jiongke Wang;Amr A.Badreldin;Xiyao Li;Bo Yu;Cun-Yu Wang
作者机构：
Laboratory of Molecular Signaling,Division of Oral and Systemic Health Sciences,School of Dentistry,UCLA,Los Angeles,CA,USA;Jonsson Comprehensive Cancer Center,UCLA,Los Angeles,CA,USA;Section of Endodontics,Division of Regenerative and Reconstructive Sciences,School of Dentistry,UCLA,Los Angeles,CA,USA;Division of Preventive and Restorative Sciences,School of Dentistry,UCLA,Los Angeles,CA,USA;Department of Bioengineering,Henry Samueli School of Engineering and Applied Science,UCLA,Los Angeles,CA,USA
文献出处：
引用格式：
[1]Peng Deng;Insoon Chang;Jiongke Wang;Amr A.Badreldin;Xiyao Li;Bo Yu;Cun-Yu Wang-.Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging)[J].国际口腔科学杂志（英文版）,2022(02):145-155
A类：
KDM4B,OMSCs,
Bone
B类：
Loss,impairs,osteogenic,differentiation,promotes,oral,bone,aging,INTRODUCTION,dynamic,that,consists,inorganic,minerals,proteins,cells,lipids,water,serves,essential,mechanical,homeostatic,functions,However,relative,proportions,components,change,over,With,deterioration,bony,microarchitecture,rise,adiposity,accompanies,reduction,trabecular,volume,early,age,gradual,mass,may,initiate,become,impaired,fragility,fracture,delayed,healing,significantly,affect,well,being,population,In,addition,imbalance,homeostasis,fat,accumulates,advance,denoting,critical,risk,developing,metabolic,disorders,such,osteoporosis
AB值：
0.663788
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
