Exercise and brain health: Physical activity helps promote and maintain our brain health, including memory and cognitive performance. Research has shown that exercise is a safe behavioral intervention that reduces the risk of hypokinetic diseases, such as hypertension, diabetes, and lipid metabolic disorders. In addition, accumulating evidence now suggests that increased physical activity has positive effects in both preventing and ameliorating multiple brain diseases, including stroke. Although stroke is often accompanied by severe long-term disability and dementia, exercise is considered effective in enhancing neurological functions, even in stroke patients. Recent systematic reviews and meta-analyses indicate that aerobic physical activity promotes multiple health outcomes, including neurological behaviors and cognitive performance in stroke patients (Luo et al., 2020). Pre-clinical studies using rodent models of stroke have also demonstrated that exercise has therapeutic potential by influencing neuroinflammation, neuroprotection, remyelination, and astrogliosis (Svensson et al., 2015). Because aging is a major risk factor for stroke, and because polypharmacy among older adult patients has become a serious social issue around the world, it is worthwhile pursuing the potential of exercise as a non-pharmacological therapy for stroke.

Keita Kinoshita;Kelly K.Chung;Hiroshi Katsuki;Ken Arai

Neuroprotection Research Laboratory,Departments of Radiology and Neurology,Massachusetts General Hospital and Harvard Medical School,Charlestown,MA,USA;Department of Chemico-Pharmacological Sciences,Graduate School of Pharmaceutical Sciences,Kumamoto University,Kumamoto,Japan

中国神经再生研究（英文版）

[1]Keita Kinoshita;Kelly K.Chung;Hiroshi Katsuki;Ken Arai-.Therapeutic potential of prophylactic exercise for intracerebral hemorrhage)[J].中国神经再生研究（英文版）,2022(07):1484-1485

hypokinetic,astrogliosis,Svensson,polypharmacy

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