典型文献
3D-printed,bi-layer,biomimetic artificial periosteum for boosting bone regeneration
文献摘要：
Periosteum,a membrane covering the surface of the bone,plays an essential role in maintaining the function of bone tis-sue—and especially in providing nourishment and vascularization during the bone regeneration process.Currently,most artificial periostea have relatively weak mechanical strength and a rapid degradation rate,and they lack integrated angio-genesis and osteogenesis functions.In this study,a bi-layer,biomimetic,artificial periosteum composed of a methacrylated gelatin-nano-hydroxyapatite(GelMA-nHA)cambium layer and a poly(N-acryloyl 2-lycine)(PACG)-GelMA-Mg2+fibrous layer was fabricated via 3D printing.The GelMA-nHA layer is shown to undertake the function of improving osteogenic differentiation of rat bone marrow mesenchymal stem cells with the sustainable release of Ca2+from nHA nanoparticles.The hydrogen-bonding-strengthened P(ACG-GelMA-L)-Mg2+hydrogel layer serves to protect the inner defect site and prolong degradation time(60 days)to match new bone regeneration.Furthermore,the released magnesium ion exhibits a prominent effect in regulating the polarization phenotype of macrophage cells into the M2 phenotype and thus promotes the angiogenesis of the human umbilical vein endothelial cells in vitro.This bi-layer artificial periosteum was implanted into a critical-sized cranial bone defect in rats,and the 12-week post-operative outcomes demonstrate optimal new bone regeneration.
文献关键词：
中图分类号：
作者姓名：
Yage Sun;Ziwei Gao;Xiaoping Zhang;Ziyang Xu;Yahan Zhang;Binbin He;Rong Yang;Qian Zhang;Qiang Yang;Wenguang Liu
作者机构：
School of Material Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin 300350,China;Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin 300211,China
文献出处：
引用格式：
[1]Yage Sun;Ziwei Gao;Xiaoping Zhang;Ziyang Xu;Yahan Zhang;Binbin He;Rong Yang;Qian Zhang;Qiang Yang;Wenguang Liu-.3D-printed,bi-layer,biomimetic artificial periosteum for boosting bone regeneration)[J].生物设计与制造（英文）,2022(03):540-555
A类：
periosteum,Periosteum,nourishment,periostea,methacrylated,acryloyl,lycine,Mg2+fibrous,Ca2+from,Mg2+hydrogel
B类：
printed,layer,biomimetic,artificial,boosting,bone,regeneration,membrane,covering,surface,plays,essential,role,maintaining,tis,sue,especially,providing,vascularization,during,process,Currently,most,have,relatively,weak,mechanical,rapid,degradation,they,lack,integrated,osteogenesis,functions,In,this,study,composed,gelatin,hydroxyapatite,GelMA,nHA,cambium,poly,PACG,was,fabricated,via,printing,shown,undertake,improving,osteogenic,differentiation,marrow,mesenchymal,stem,cells,sustainable,nanoparticles,hydrogen,bonding,strengthened,serves,protect,inner,defect,site,prolong,days,match,new,Furthermore,released,magnesium,exhibits,prominent,effect,regulating,polarization,phenotype,macrophage,into,M2,thus,promotes,angiogenesis,human,umbilical,vein,endothelial,vitro,This,implanted,critical,sized,cranial,rats,week,post,operative,outcomes,demonstrate,optimal
AB值：
0.535825
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
