典型文献
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
文献摘要：
Cancer immunotherapy has significantly flourished and revolutionized the limited conven-tional tumor therapies,on account of its good safety and long-term memory ability.Discouragingly,low patient response rates and potential immune-related side effects make it rather challenging to literally bring immunotherapy from bench to bedside.However,it has become evident that,although the immu-nosuppressive tumor microenvironment(TME)plays a pivotal role in facilitating tumor progression and metastasis,it also provides various potential targets for remodeling the immunosuppressive TME,which can consequently bolster the effectiveness of antitumor response and tumor suppression.Additionally,the particular characteristics of TME,in turn,can be exploited as avenues for designing diverse precise tar-geting nanomedicines.In general,it is of urgent necessity to deliver nanomedicines for remodeling the immunosuppressive TME,thus improving the therapeutic outcomes and clinical translation prospects of immunotherapy.Herein,we will illustrate several formation mechanisms of immunosuppressive TME.More importantly,a variety of strategies concerning remodeling immunosuppressive TME and strengthening patients'immune systems,will be reviewed.Ultimately,we will discuss the existing obsta-cles and future perspectives in the development of antitumor immunotherapy.Hopefully,the thriving bloom of immunotherapy will bring vibrancy to further exploration of comprehensive cancer treatment.
文献关键词：
中图分类号：
作者姓名：
Yanyan Xu;Jingyuan Xiong;Xiyang Sun;Huile Gao
作者机构：
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China;Healthy Food Evaluation Research Center,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China;Hongqiao International Institute of Medicine,Tongren Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200336,China
文献出处：
引用格式：
[1]Yanyan Xu;Jingyuan Xiong;Xiyang Sun;Huile Gao-.Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy)[J].药学学报（英文版）,2022(12):4327-4347
A类：
Discouragingly,nosuppressive
B类：
Targeted,nanomedicines,remodeling,immunosuppressive,microenvironment,enhanced,cancer,immunotherapy,Cancer,has,significantly,flourished,revolutionized,limited,conven,therapies,account,its,good,safety,long,term,memory,ability,low,response,rates,potential,immune,related,effects,make,rather,challenging,literally,bring,from,bench,bedside,However,become,evident,that,although,TME,plays,pivotal,role,facilitating,progression,metastasis,also,provides,various,targets,which,consequently,bolster,effectiveness,antitumor,suppression,Additionally,particular,characteristics,turn,exploited,avenues,designing,diverse,precise,geting,In,general,urgent,necessity,deliver,thus,improving,therapeutic,outcomes,clinical,translation,prospects,Herein,will,illustrate,several,formation,mechanisms,More,importantly,variety,strategies,concerning,strengthening,patients,systems,reviewed,Ultimately,discuss,existing,obsta,cles,future,perspectives,development,Hopefully,thriving,bloom,vibrancy,further,exploration,comprehensive,treatment
AB值：
0.616354
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