典型文献
Perfluorooctyl bromide nanoemulsions holding MnO2 nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death
文献摘要：
Tumor-targeted immunotherapy is a remarkable breakthrough,offering the inimitable advan-tage of specific tumoricidal effects with reduced immune-associated cytotoxicity.However,existing plat-forms suffer from low efficacy,inability to induce strong immunogenic cell death(ICD),and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones.Here,an innovative plat-form,perfluorooctyl bromide(PFOB)nanoemulsions holding MnO2 nanoparticles(MBP),was developed to orchestrate cancer immunotherapy,serving as a theranostic nanoagent for MRI/CT dual-modality im-aging and advanced ICD.By simultaneously depleting the GSH and eliciting the ICD effect via high-intensity focused ultrasound(HIFU)therapy,the MBP nanomedicine can regulate the tumor immune microenvironment by inducing maturation of dendritic cells(DCs)and facilitating the activation of CD8+and CD4+T cells.The synergistic GSH depletion and HIFU ablation also amplify the inhibition of tumor growth and lung metastasis.Together,these findings inaugurate a new strategy of tumor-targeted immu-notherapy,realizing a novel therapeutics paradigm with great clinical significance.
文献关键词：
中图分类号：
作者姓名：
Xinping Kuai;Yuefei Zhu;Zheng Yuan;Shengyu Wang;Lin Lin;Xiaodan Ye;Yiping Lu;Yu Luo;Zhiqing Pang;Daoying Geng;Bo Yin
作者机构：
Department of Radiology,Huashan Hospital,Fudan University,Shanghai 200040,China;School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery,Ministry of Education,Shanghai 201203,China;Department of Radiology,Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai 201204,China;Department of Radiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201800,China;Department of Radiology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure,School of Chemical Science and Engineering,Shanghai 200092,China
文献出处：
引用格式：
[1]Xinping Kuai;Yuefei Zhu;Zheng Yuan;Shengyu Wang;Lin Lin;Xiaodan Ye;Yiping Lu;Yu Luo;Zhiqing Pang;Daoying Geng;Bo Yin-.Perfluorooctyl bromide nanoemulsions holding MnO2 nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death)[J].药学学报（英文版）,2022(02):967-981
A类：
Perfluorooctyl,inimitable,tumoricidal,deserted,perfluorooctyl,PFOB,nanoagent,CD8+and,notherapy
B类：
bromide,nanoemulsions,holding,MnO2,nanoparticles,dual,modality,imaging,glutathione,depletion,enhanced,HIFU,eliciting,immunogenic,death,Tumor,targeted,immunotherapy,remarkable,breakthrough,offering,tage,specific,effects,reduced,immune,associated,cytotoxicity,However,existing,plat,forms,suffer,from,low,efficacy,inability,induce,strong,ICD,restrained,capacity,transforming,tumors,into,cultivated,ones,Here,innovative,MBP,was,developed,orchestrate,cancer,serving,theranostic,advanced,By,simultaneously,depleting,GSH,via,high,intensity,focused,ultrasound,nanomedicine,regulate,microenvironment,by,inducing,maturation,dendritic,cells,DCs,facilitating,activation,CD4+T,synergistic,ablation,also,amplify,inhibition,growth,lung,metastasis,Together,these,findings,inaugurate,new,strategy,realizing,novel,therapeutics,paradigm,great,clinical,significance
AB值：
0.59103
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