典型文献
Nanomedicine enables efficient CRISPR-Cas9 genome editing for disease treatment
文献摘要：
In recent years,the clustered regularly interspaced short palin-dromic repeats-associated protein 9(CRISPR-Cas9)technology that won the 2020 Nobel Prize in Chemistry has served as one of the most prominent and powerful tools in gene editing for biomedical research and the treatment of various diseases[1].Nevertheless,it remains a substantial challenge to effectively and safely deliver CRISPR-Cas9 molecules into target cells[2].Viral-based carriers have been broadly used in CRISPR-Cas9 delivery,but there are still some intrinsic flaws,such as low packing capacity,tumorigenesis,immunogenicity,and off-target editing effects,which greatly hin-der their clinical translation[3].Alternatively,a nonviral nanoma-terial-based delivery strategy is becoming increasingly promising due to its low toxicity,high delivery efficiency,specific targeting and minor stimulation of the immune response[4].Engineered nanomaterial delivery systems hold great potential to advance the implementation of CRISPR-Cas9 technology.From this perspec-tive,we discuss and highlight how the latest promising nanomate-rial systems overcome some long-term challenges in CRISPR-Cas9 gene editing and provide our point of view on the remaining obsta-cles and future directions for the clinical implementation of nano-medicine-based CRISPR-Cas9 modalities.
文献关键词：
中图分类号：
作者姓名：
Lifang Ma;Caihong Dong;Meihua Yu;Xinran Song;Yongchun Yu;Yu Chen
作者机构：
Shanghai Institute of Thoracic Oncology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China;Department of Clinical Laboratory Medicine,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China;Department of Ultrasound,Zhongshan Hospital,Fudan University,and Shanghai Institute of Medical Imaging,Shanghai 200032,China;Materdicine Laboratory,School of Life Sciences,Shanghai University,Shanghai 200444,China
文献出处：
引用格式：
[1]Lifang Ma;Caihong Dong;Meihua Yu;Xinran Song;Yongchun Yu;Yu Chen-.Nanomedicine enables efficient CRISPR-Cas9 genome editing for disease treatment)[J].科学通报（英文版）,2022(06):572-576
A类：
palin,dromic,nonviral
B类：
Nanomedicine,enables,efficient,CRISPR,Cas9,genome,editing,treatment,In,recent,years,clustered,regularly,interspaced,short,repeats,associated,protein,technology,that,won,Nobel,Prize,Chemistry,has,served,one,most,prominent,powerful,tools,biomedical,research,various,diseases,Nevertheless,remains,substantial,effectively,safely,molecules,into,cells,Viral,carriers,have,been,broadly,used,delivery,but,there,are,still,some,intrinsic,flaws,such,low,packing,capacity,tumorigenesis,immunogenicity,off,effects,which,greatly,hin,der,their,clinical,translation,Alternatively,strategy,becoming,increasingly,promising,due,its,toxicity,efficiency,specific,targeting,minor,stimulation,immune,response,Engineered,nanomaterial,systems,hold,potential,advance,implementation,From,this,perspec,discuss,highlight,how,latest,overcome,long,term,challenges,provide,our,point,view,remaining,obsta,cles,future,directions,modalities
AB值：
0.634005
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