Since 2005,GLP-1 receptor(GLP-1R)agonists(GLP-1RAs)have been developed as thera-peutic agents for type 2 diabetes(T2D).GLP-1R is not only expressed in pancreatic islets but also other organs,especially the lung.However,controversy on extra-pancreatic GLP-1R expression still needs to be further resolved,utilizing different tools including the use of more reliable GLP-1R antibodies in immune-staining and co-immune-staining.Extra-pancreatic expression of GLP-1R has triggered exten-sive investigations on extra-pancreatic functions of GLP-1RAs,aiming to repurpose them into therapeutic agents for other disorders.Extensive studies have demonstrated promising anti-inflammatory features of GLP-1RAs.Whether those features are directly mediated by GLP-1R expressed in immune cells also re-mains controversial.Following a brief review on GLP-1 as an incretin hormone and the development of GLP-lRAs as therapeutic agents for T2D,we have summarized our current understanding of the anti-inflammatory features of GLP-1RAs and commented on the controversy on extra-pancreatic GLP-1R expression.The main part of this review is a literature discussion on GLP-1RA utilization in animal models with chronic airway diseases and acute lung injuries,including studies on the combined use of mesenchymal stem cell(MSC)based therapy.This is followed by a brief summary.

Juan Pang;Jia Nuo Feng;Wenhua Ling;Tianru Jin

Department of Nutrition,School of Public Health,Sun Yat-sen Universitynstitute,Guangzhou 510080,China;Division of Advanced Diagnostics,Toronto General Hospital Research I,University Health Network,Toronto M5G 1L7,Canada;Department of Physiology,Faculty of Medicine,University of Toronto,Toronto M5S 1A1,Canada;Banting and Best Diabetes Centre,Faculty of Medicine,University of Toronto,Toronto M5G 2C4,Canada

药学学报（英文版）

[1]Juan Pang;Jia Nuo Feng;Wenhua Ling;Tianru Jin-.The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury)[J].药学学报（英文版）,2022(11):4040-4055

repurpose,lRAs

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