典型文献
Cancer metabolism and dietar y inter ventions
文献摘要：
Metabolic remodeling is a key feature of cancer development. Knowledge of cancer metabolism has greatly expanded since the first observation of abnormal metabolism in cancer cells, the so-called Warburg effect. Malignant cells tend to modify cellular metabolism to favor specialized fermentation over the aerobic respiration usually used by most normal cells. Thus, targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have received substantial attention both conceptually and in clinical practice. In particular, the management of nutrient availability is becoming more attractive in cancer treatment. In this review, we discuss recent findings on tumor metabolism and potential dietary interventions based on the specific characteristics of tumor metabolism. First, we present a comprehensive overview of changes in macronutrient metabolism. Carbohydrates, amino acids, and lipids, are rewired in the cancer microenvironment individually or systematically. Second, we summarize recent progress in cancer interventions applying different types of diets and specific nutrient restrictions in pre-clinical research or clinical trials.
文献关键词：
中图分类号：
作者姓名：
Lin Qian;Fan Zhang;Miao Yin;Qunying Lei
作者机构：
Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences,Cancer Institutes,Key Laboratory of Breast Cancer in Shanghai,Shanghai Key Laboratory of Radiation Oncology,Shanghai Key Laboratory of Medical Epigenetics,Shanghai Medical College,Fudan University,Shanghai 200030,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200030,China;State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200030,China;Lead Contact,Shanghai 200030,China
文献出处：
引用格式：
[1]Lin Qian;Fan Zhang;Miao Yin;Qunying Lei-.Cancer metabolism and dietar y inter ventions)[J].癌症生物学与医学（英文版）,2022(02):163-174
A类：
dietar,ventions,rewired
B类：
Cancer,metabolism,Metabolic,remodeling,key,feature,cancer,development,Knowledge,has,greatly,expanded,since,first,observation,abnormal,cells,so,called,Warburg,effect,Malignant,tend,modify,cellular,favor,specialized,fermentation,aerobic,respiration,usually,used,by,most,Thus,targeted,therapies,reprogramming,metabolite,have,received,substantial,attention,both,conceptually,clinical,practice,In,particular,management,availability,becoming,more,attractive,treatment,this,review,we,discuss,recent,findings,tumor,potential,dietary,interventions,specific,characteristics,First,present,comprehensive,overview,changes,macronutrient,Carbohydrates,amino,acids,lipids,are,microenvironment,individually,systematically,Second,summarize,progress,applying,different,types,diets,restrictions,research,trials
AB值：
0.641003
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