Diabetes mellitus is a global public health problem that causes great economic and social burdens.Its pathogenesis is complex and unclear.Recently,with considerable attention paid to the interaction between gut microbiota and host,gut microbiota has been found to play an important role in several chronic diseases,including diabetes.In 2012,the first metagenomic study on the role of gut microbiota in diabetes was reported,which revealed that the gut metagenomes in patients with type 2 diabetes(T2D)present moderate gut microbiota dysbiosis,with fewer butyrate-producing bacteria and more opportunistic pathogens[1].In 2013,it was shown that a model based on microbiota composition and function can identify patients with T2D[2].In 2017,the involvement of gut microbiota alteration in metformin's antidia-betic effects was explored,and metal homeostasis was suggested to be responsible for this impact[3].In 2018,a clinical trial pro-posed that the abundance of specific gut microbiota species,mod-ulated by dietary fiber,alleviates T2D by producing short-chain fatty acids(SCFAs),and the reestablishment of this effective gut microbiome using personalized nutrition may offer a possible approach for T2D management[4].Furthermore,gut microbiota may be responsible for the varied responses of individuals to exer-cise interventions on glucose metabolism[5].In this context,we aim to discuss the recent mechanistic discoveries regarding the contribution of gut microbiota to diabetes and the innovative ther-apeutic values of gut microbiota for diabetes.

Weiping Jia;Gianni Panagiotou

Shanghai Key Laboratory of Diabetes Mellitus,Department of Endocrinology and Metabolism,Shanghai Diabetes Institute,Shanghai Clinical Center for Diabetes,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China;Systems Biology and Bioinformatics Unit,Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoll Institute,Jena 07745,Germany;State Key Laboratory of Pharmaceutical Biotechnology,The University of Hong Kong,Hong Kong,China;Department of Medicine,The University of Hong Kong,Hong Kong,China

科学通报（英文版）

[1]Weiping Jia;Gianni Panagiotou-.Recent advances in diabetes and microbiota)[J].科学通报（英文版）,2022(17):1720-1723

metagenomes,antidia,reestablishment

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