典型文献
AMP-activated protein kinase β1 or β2 deletion enhances colon cancer cell growth and tumorigenesis
文献摘要：
Abnormal metabolism is a major hallmark of cancer and has been validated as a therapeutic target.Adenine monophosphate-activated protein kinase(AMPK),an αβγ heterotrimer,performs essential functions in cancer progression due to its central role in maintaining the homeostasis of cellular energy.While the contributions of AMPKα and AMPKγ subunits to cancer development have been established,specific roles of AMPKβ1 and AMPKβ2 isoforms in cancer development are poorly understood.Here,we show the functions of AMPKβ1 and AMPKβ2 in colon cancer.Specifically,deletion of AMPKβ1 or AMPKβ2 leads to increased cell proliferation,colony formation,migration,and tumorigenesis in HCT116 and HT29 colon cancer cells.Interestingly,the AMPKβ1 and AMPKβ2 isoforms have slightly different effects on regulating cancer metabolism,as colon cancer cells with AMPKβ1 knockout showed decreased rates of glycolysis-related oxygen consumption,while AMPKβ2 deletion led to en-hanced rates of oxygen consumption due to oxidative phosphorylation.These results demonstrate that functional AMPKβ1 and AMPKβ2 inhibit growth and tumorigenesis in colon cancer cells,suggesting their potential as effective targets for colon cancer therapy.
文献关键词：
中图分类号：
作者姓名：
Fuli Shi;Zhimin Tang;Shanshan Jiang;Zhijuan Xiong;Wansi Zhang;Yuanjun Li;Hui Lin;Zhijun Luo;Ying Ying
作者机构：
Jiangxi Medical Center for Major Public Health Events,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Immunobiology,College of Life Science and Technology,Jinan University,Guangzhou 510632,China;Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology and Department of Pathophysiology,School of Basic Medical Sciences,Nanchang University,Nanchang 330006 China;Institute of Hematological Research,Shaanxi Provincial People's Hospital,Xi'an 710000,China;Departments of Gastroenterology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China
文献出处：
引用格式：
[1]Fuli Shi;Zhimin Tang;Shanshan Jiang;Zhijuan Xiong;Wansi Zhang;Yuanjun Li;Hui Lin;Zhijun Luo;Ying Ying-.AMP-activated protein kinase β1 or β2 deletion enhances colon cancer cell growth and tumorigenesis)[J].生物化学与生物物理学报（英文版）,2022(08):1140-1147
A类：
heterotrimer
B类：
activated,protein,kinase,deletion,enhances,cancer,growth,tumorigenesis,Abnormal,metabolism,major,hallmark,has,been,validated,therapeutic,Adenine,monophosphate,AMPK,performs,essential,functions,progression,due,central,maintaining,homeostasis,cellular,energy,While,contributions,subunits,development,have,established,specific,roles,isoforms,are,poorly,understood,Here,Specifically,leads,increased,proliferation,colony,formation,migration,HCT116,HT29,cells,Interestingly,slightly,different,effects,regulating,knockout,showed,decreased,rates,glycolysis,related,oxygen,consumption,while,led,hanced,oxidative,phosphorylation,These,results,demonstrate,that,functional,inhibit,suggesting,their,potential,effective,targets,therapy
AB值：
0.517952
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