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典型文献
Targeting cyclin-dependent kinase 9 in cancer therapy
文献摘要:
Cyclin-dependent kinase(CDK)9 associates mainly with cyclin T1 and forms the positive transcription elongation factor b(p-TEFb)complex responsible for transcriptional regulation.It has been shown that CDK9 modulates the expression and activity of oncogenes,such as MYC and murine double minute 4(MDM4),and it also plays an important role in development and/or maintenance of the malignant cell phenotype.Malfunction of CDK9 is frequently observed in numerous cancers.Recent studies have highlighted the function of CDK9 through a variety of mechanisms in cancers,including the formation of new complexes and epigenetic alterations.Due to the importance of CDK9 activation in cancer cells,CDK9 inhibitors have emerged as promising candidates for cancer therapy.Natural product-derived and chemically synthesized CDK9 inhibitors are being examined in preclinical and clinical research.In this review,we summarize the current knowledge on the role of CDK9 in transcriptional regulation,epigenetic regulation,and different cellular factor interactions,focusing on new advances.We show the importance of CDK9 in mediating tumorigenesis and tumor progression.Then,we provide an overview of some CDK9 inhibitors supported by multiple oncologic preclinical and clinical investigations.Finally,we discuss the perspective and challenge of CDK9 modulation in cancer.
文献关键词:
作者姓名:
Yi-li Shen;Yan-mao Wang;Ya-xin Zhang;Shen-jie Ma;Le-he Yang;Cheng-guang Zhao;Xiao-ying Huang
作者机构:
Division of Pulmonary Medicine,The First Affiliated Hospital of Wenzhou Medical University,Key Laboratory of Heart and Lung,Wenzhou 325000,China;School of Pharmaceutical Sciences,Wenzhou Medical University,University Town,Wenzhou 325035,China
引用格式:
[1]Yi-li Shen;Yan-mao Wang;Ya-xin Zhang;Shen-jie Ma;Le-he Yang;Cheng-guang Zhao;Xiao-ying Huang-.Targeting cyclin-dependent kinase 9 in cancer therapy)[J].中国药理学报(英文版),2022(07):1633-1645
A类:
TEFb
B类:
Targeting,cyclin,dependent,kinase,therapy,Cyclin,associates,mainly,forms,positive,elongation,responsible,transcriptional,regulation,It,has,been,shown,that,CDK9,modulates,expression,activity,oncogenes,such,MYC,murine,double,minute,MDM4,also,plays,important,role,development,maintenance,malignant,phenotype,Malfunction,frequently,observed,numerous,cancers,Recent,studies,have,highlighted,through,variety,mechanisms,including,formation,new,complexes,epigenetic,alterations,Due,importance,activation,cells,inhibitors,emerged,promising,candidates,Natural,product,derived,chemically,synthesized,are,being,examined,preclinical,research,In,this,review,we,summarize,current,knowledge,different,cellular,interactions,focusing,advances,We,mediating,tumorigenesis,progression,Then,provide,overview,some,supported,by,multiple,oncologic,investigations,Finally,discuss,perspective,challenge,modulation
AB值:
0.586219
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