典型文献
Iron metabolism, ferroptosis, and lncRNA in cancer:knowns and unknowns
文献摘要：
Cancer cells undergo substantial metabolic alterations to sustain increased energy supply and uncontrolled proliferation. As an essential trace element, iron is vital for many biological processes. Evidence has revealed that cancer cells deploy various mechanisms to elevate the cellular iron concentration to accelerate proliferation. Ferroptosis, a form of cell death caused by iron-catalyzed excessive peroxidation of polyunsaturated fatty acids (PUFAs), is a promising therapeutic target for therapy-resistant cancers. Previous studies have reported that long noncoding RNA (lncRNA) is a group of critical regulators involved in modulating cell metabolism, proliferation, apoptosis, and ferroptosis. In this review, we summarize the associations among iron metabolism, ferroptosis, and ferroptosis-related lncRNA in tumorigenesis. This information will help deepen understanding of the role of lncRNA in iron metabolism and raise the possibility of targeting lncRNA and ferroptosis in cancer combination therapy.
文献关键词：
中图分类号：
作者姓名：
Lei QU;Xinyu HE;Qian TANG;Xiao FAN;Jian LIU;Aifu LIN
作者机构：
MOE Laboratory of Biosystem Homeostasis and Protection,College of Life Sciences,Zhejiang University,Hangzhou 310058,China;Cancer Center,Zhejiang University,Hangzhou 310058,China;Key Laboratory for Cell and Gene Engineering of Zhejiang Province,Hangzhou 310058,China;Zhejiang University-University of Edinburgh Institute(ZJU-UoE Institute),Zhejiang University School of Medicine,Zhejiang University,Haining 314400,China;Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,Cancer Center,Zhejiang University School of Medicine,Hangzhou 310006,China;College of Medicine and Veterinary Medicine,the University of Edinburgh,Edinburgh EH164SB,UK;Biomedical and Health Translational Research Center of Zhejiang Province,Haining 314400,China;Breast Center of the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;International School of Medicine,International Institutes of Medicine,the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu 322000,China;ZJU-QILU Joint Research Institute,Hangzhou 310058,China
引用格式：
[1]Lei QU;Xinyu HE;Qian TANG;Xiao FAN;Jian LIU;Aifu LIN-.Iron metabolism, ferroptosis, and lncRNA in cancer:knowns and unknowns)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(10):844-862
A类：
knowns
B类：
Iron,metabolism,ferroptosis,lncRNA,unknowns,Cancer,cells,undergo,substantial,metabolic,alterations,sustain,increased,energy,supply,uncontrolled,proliferation,essential,trace,element,iron,vital,many,biological,processes,Evidence,has,revealed,that,deploy,various,mechanisms,elevate,cellular,concentration,accelerate,Ferroptosis,death,caused,by,catalyzed,excessive,peroxidation,polyunsaturated,fatty,acids,PUFAs,promising,therapeutic,therapy,resistant,cancers,Previous,studies,have,reported,long,noncoding,group,critical,regulators,involved,modulating,apoptosis,In,this,review,we,summarize,associations,among,related,tumorigenesis,This,information,will,help,deepen,understanding,role,raise,possibility,targeting,combination
AB值：
0.668643
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