The phosphosphatidylinositol-3-kinase (PI3K) signaling pathway is one of the most important intracellular signal transduction pathways affecting cell functions, such as apoptosis, translation, metabolism, and angiogenesis. Lung cancer is a malignant tumor with the highest morbidity and mortality rates in the world. It can be divided into two groups, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC accounts for >85% of all lung cancers. There are currently many clinical treatment options for NSCLC; however, traditional methods such as surgery, chemotherapy, and radiotherapy have not been able to provide patients with good survival benefits. The emergence of molecular target therapy has improved the survival and prognosis of patients with NSCLC. In recent years, there have been an increasing number of studies on NSCLC and PI3K signaling pathways. Inhibitors of various parts of the PI3K pathway have appeared in various phases of clinical trials with NSCLC as an indication. This article focuses on the role of the PI3K signaling pathway in the occurrence and development of NSCLC and summarizes the current clinical research progress and possible development strategies.

Phosphosphatidylinositol-3-kinase signaling pathway;Protein kinase B;Mammalian target of rapamycin;Non-small cell lung cancer

Jiang Lin;Zhang Jingbo;Xu Yan;Xu Heng;Wang Mengzhao

Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

中华医学杂志（英文版）

[1]Jiang Lin;Zhang Jingbo;Xu Yan;Xu Heng;Wang Mengzhao-.Treating non-small cell lung cancer by targeting the PI3K signaling pathway)[J].中华医学杂志（英文版）,2022(11):1272-1284

phosphosphatidylinositol,Phosphosphatidylinositol

Treating,small,lung,by,targeting,PI3K,signaling,kinase,one,most,important,intracellular,transduction,pathways,affecting,functions,such,apoptosis,translation,metabolism,angiogenesis,Lung,malignant,tumor,highest,morbidity,mortality,rates,world,It,divided,into,two,groups,NSCLC,accounts,cancers,There,currently,many,clinical,treatment,options,however,traditional,methods,surgery,chemotherapy,radiotherapy,have,not,been,able,provide,patients,good,survival,benefits,emergence,molecular,improved,prognosis,recent,years,there,increasing,number,studies,Inhibitors,various,parts,appeared,phases,trials,indication,This,article,focuses,role,occurrence,development,summarizes,research,progress,possible,strategies,Protein,Mammalian,rapamycin,Non

0.528507