典型文献
Facile preparation of 177Lu-microspheres for hepatocellular carcinoma radioisotope therapy
文献摘要：
As one of the most common cancers in the world,hepatocellular carcinoma(HCC)has become a ma-jor threat to human health.Radioembolization is a first-line option for the treatment of HCC,especially when other conventional treatments fail or there exist some relative contraindications.Herein,we de-veloped a facile and efficient method for preparing 177Lu-microspheres potentially useful for precise ra-dioembolization therapy of HCC.The radiolabeling efficiency of 177Lu-microspheres was as high as 96.8％±0.5％,and the radiolabeling process did not alter the morphology of the mother microspheres.The SPECT/CT studies enabled by the unique emissions of 177Lu suggested that almost no 177Lu ion loaded by the microspheres was released over more than 32 d in vivo,which led to remarkable inhibition effect on the growth of HepG2 tumors subcutaneously transplanted in mice.The current approach may thus offer promising 177Lu-microspheres for clinical radioembolization of HCC.
文献关键词：
中图分类号：
作者姓名：
Manran Wu;Kexin Shi;Ruizhe Huang;Chunyi Liu;Lingling Yin;Weipeng Yong;Jing Sun;Guanglin Wang;Zhiyuan Zhong;Mingyuan Gao
作者机构：
State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China;Biomedical Polymers Laboratory,College of Chemistry,Chemical Engineering and Materials Science,State Key Laboratory of Radiation Medicine and Protection,Soochow University,Suzhou 215123,China
文献出处：
引用格式：
[1]Manran Wu;Kexin Shi;Ruizhe Huang;Chunyi Liu;Lingling Yin;Weipeng Yong;Jing Sun;Guanglin Wang;Zhiyuan Zhong;Mingyuan Gao-.Facile preparation of 177Lu-microspheres for hepatocellular carcinoma radioisotope therapy)[J].中国化学快报（英文版）,2022(07):3492-3496
A类：
radioisotope,Radioembolization,dioembolization,radiolabeling,radioembolization
B类：
Facile,preparation,177Lu,microspheres,hepatocellular,carcinoma,therapy,one,common,cancers,world,HCC,has,become,jor,threat,human,health,first,line,option,especially,when,conventional,treatments,fail,there,exist,some,relative,contraindications,Herein,we,veloped,facile,efficient,method,preparing,potentially,useful,precise,efficiency,was,high,process,did,not,alter,morphology,mother,SPECT,studies,enabled,by,unique,emissions,suggested,that,almost,loaded,released,over,more,than,vivo,which,remarkable,inhibition,effect,growth,HepG2,tumors,subcutaneously,transplanted,mice,current,approach,may,thus,offer,promising,clinical
AB值：
0.565823
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