(上续本刊2022年1期20页) 2. 2 剂量相关参考浓度范围 对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围.治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题.后者比较的是测得的药物浓度与理论预期药物浓度范围.参照药代动力学研究,优先考虑没有合并用药或药物基因组异常的患者群("正常"患者) ,在日维持剂量( Daily maintenance dose, Dm)、给药间隔(Dosing interval,di)、总清除率(Total clear-ance,CL)和生物利用度( Bioavailability,F)已知情况下,某种药物在某个"正常"患者体内的预期平均稳态浓度( Aver-age steady-state concentration,Cav )可通过下面的公式计算:

C. Hiemke;N. Bergemann;H. W. Clement;A. Conca;J. Deckert;K. Domschke;G. Eckermann;K. Egberts;M. Gerlach;C. Greiner;G. Gründer;E. Haen;U. Havemann-Reinecke;G. Hefner;R. Helmer;G. Janssen;E. Jaquenoud;G. Laux;T. Messer;R. M?ssner;M. J. Müller;M. Paulzen;B. Pfuhlmann;P. Riederer;A. Saria;B. Schoppek;G. Schoretsanitis;M. Schwarz;M.Silva Gracia;B. Stegmann;W. Steimer;J. C. Stingl;M. Uhr;S. Ulrich;S. Unterecker;R. Waschgler;G. Zernig;G. Zurek;P. Baumann;李文标;果伟;贺静;鲍爽;路钊;牛梦溪;阮灿军;臧彦楠;王勇;张玲;刘辰庚;李洁

Department of Psychiatry and Psychotherapy,University Medical Center of Mainz,Mainz,Germany;Institute of Clinical Chemistry and Laboratory Medicine,University Medical Center of Mainz,Mainz,Germany;Kitzberg Hospitals,Center for Psychosomatic Medicine and Psychotherapy,Bad Mergentheim,Germany;Department of Child and Adolescent Psychiatry,University of Freiburg,Freiburg,Germany;Servizio Psichiatrico del Comprensorio Sanitario di Bolzano,Bolzano,Italy;Department of Psychiatry,Psychotherapy and Psychosomatics,University Hospital of Würzburg,Germany;Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg,Freiburg,Germany;Psychiatric Hospital,Kaufbeuren,Germany;Department of Child and Adolescent Psychiatry,Psychosomatics and Psychotherapy,Center of Mental Health,University Hospi-tal of Würzburg,Germany;Federal Institute for Drugs and Medical Devices (BfArM),Bonn,Germany;Department of Psychiatry,Psychotherapy and Psychosomatics,RWTH Aachen University,Aachen,and JARA–Translational Brain Medicine,Aachen,Germany;Clinical Pharmacology,Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology,Uni-versity of Regensburg,Regensburg,Germany;Department of Psychiatry and Psychosomatics,University of G?ttingen,G?ttingen,Germany;Psychiatric Hospital,Vitos Klinik,Eichberg,Eltville,Germany;Center of Epilepsy,Bielefeld,Germany;Medical Laboratory Stein,Limbach Group,M?nchengladbach,Germany;Psychiatric Hospital,K?nigsfelden,Brugg,Aargau,Switzerland;Institute of Psychological Medicine,Haag in Oberbayern,Germany;Danuviuskliniken,Psychiatric Hospital,Pfaffenhofen,Germany;Department of Psychiatry and Psychotherapy,University of Tübingen,Tübingen,Germany;Psychiatric Hospitals Oberberggruppe,Berlin,Germany;Psychiatric Hospital Weisser Hirsch,Dresden,Germany;Experimental Psychiatry Unit,Department of Psychiatry1,Medical University of Innsbruck,Innsbruck,Austria;kbo-Isar-Amper Klinikum München-Ost,Psychiatric Hospital,Munich-Haar,Germany;Department of Psychiatry,University of Bern,Bern,Switzerland;Department of Laboratory Medicine,Ludwig Maximilian University,Munich,Germany;Institute of Clinical Chemistry and Pathobiochemistry,Technical University Munich,Munich,Germany;Max Planck Institute of Psychiatry,Munich,Germany;Aristo Pharma GmbH,Berlin,Germany;Psychiatric Hospital,Feldkirch,Austria;Private Practice for Psychotherapy and Court-Certified Witness,Hall in Tirol,Austria;Medical Laboratory Bremen,Bremen,Germany;Department of Psychiatry,University of Lausanne,Prilly-Lausanne,Switzerland;中国 北京 首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京重点实验室;中国 天津 天津市安定医院

实用药物与临床

[1]C. Hiemke;N. Bergemann;H. W. Clement;A. Conca;J. Deckert;K. Domschke;G. Eckermann;K. Egberts;M. Gerlach;C. Greiner;G. Gründer;E. Haen;U. Havemann-Reinecke;G. Hefner;R. Helmer;G. Janssen;E. Jaquenoud;G. Laux;T. Messer;R. M?ssner;M. J. Müller;M. Paulzen;B. Pfuhlmann;P. Riederer;A. Saria;B. Schoppek;G. Schoretsanitis;M. Schwarz;M.Silva Gracia;B. Stegmann;W. Steimer;J. C. Stingl;M. Uhr;S. Ulrich;S. Unterecker;R. Waschgler;G. Zernig;G. Zurek;P. Baumann;李文标;果伟;贺静;鲍爽;路钊;牛梦溪;阮灿军;臧彦楠;王勇;张玲;刘辰庚;李洁-.神经精神药理学治疗药物监测共识指南:2017版)[J].实用药物与临床,2022(02):97-118

治疗参考浓度范围,Bioavailability

药理学,治疗药物监测,共识指南, 2,TDM,药效动力学,动力学问题,药代动力学,药物浓度,参照药,动力学研究,先考,合并用药,药物基因组,维持剂量,Daily,maintenance,dose,Dm,Dosing,interval,di,清除率,Total,clear,CL,生物利用度,某个,Aver,age,steady,state,concentration,Cav,公式计算

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