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典型文献
An improved cell line-derived xenograft humanized mouse model for evaluation of PD-1/PD-L1 blocker BMS202-induced immune responses in colorectal cancer
文献摘要:
The establishment of an in vivo mouse model mimicking human tumor-immune environments provides a pro-mising platform for immunotherapy assessment,drug discovery and clinical decision guidance.To this end,we construct humanized NCG mice by transplanting human hCD34+hematopoietic progenitors into non-obese dia-betic(NOD)Cg-PrkdcscidIL2rgrm1wjl/Sz(null;NCG)mice and monitoring the development of human hematopoietic and immune systems(Hu-NCG).The cell line-derived xenograft(CDX)Hu-NCG mouse models are set up to assess the outcome of immunotherapy mediated by the small molecule BMS202.As a PD-1/PD-L1 blocker,BMS202 shows satisfactory antitumour efficacy in the HCT116 and SW480 xenograft Hu-NCG mouse models.Mechanistically,BMS202 exerts antitumour efficacy by improving the tumor microenvironment and enhancing the infiltration of hCD8+T cells and the release of hIFNγ in tumor tissue.Thus,tumor-bearing Hu-NCG mice are a suitable and important in vivo model for preclinical study,particularly in cancer immunotherapy.
文献关键词:
作者姓名:
Pengzhao Shang;Liting Yu;Shucheng Cao;Changying Guo;Wanheng Zhang
作者机构:
School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China;Department of Pharmacy,Binzhou Medical University,Yantai 264003,China;School of Engineering,China Pharmaceutical University,Nanjing 210009,China;Department of Pharmacy,the First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China
引用格式:
[1]Pengzhao Shang;Liting Yu;Shucheng Cao;Changying Guo;Wanheng Zhang-.An improved cell line-derived xenograft humanized mouse model for evaluation of PD-1/PD-L1 blocker BMS202-induced immune responses in colorectal cancer)[J].生物化学与生物物理学报(英文版),2022(10):1497-1506
A类:
BMS202,mising,hCD34+hematopoietic,PrkdcscidIL2rgrm1wjl,hCD8+T,hIFN
B类:
An,improved,line,derived,xenograft,humanized,mouse,evaluation,L1,blocker,induced,immune,responses,colorectal,cancer,establishment,vivo,mimicking,tumor,environments,provides,platform,immunotherapy,assessment,drug,discovery,decision,guidance,To,this,end,we,construct,NCG,mice,by,transplanting,progenitors,into,obese,betic,NOD,Cg,Sz,null,monitoring,development,systems,Hu,CDX,models,are,set,up,outcome,mediated,small,molecule,shows,satisfactory,antitumour,efficacy,HCT116,SW480,Mechanistically,exerts,improving,microenvironment,enhancing,infiltration,cells,release,tissue,Thus,bearing,suitable,important,preclinical,study,particularly
AB值:
0.492107
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