典型文献
The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma
文献摘要：
The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role of this signaling pathway in tumor cells. However, it is now clear that tumor development and metastasis depend on the two-way interaction between cancer cells and their environment, thereby forming a tumor microenvironment (TME). In this review, we discuss how Wnt/β-catenin signaling regulates cross-interactions among different components of the TME, including immune cells, stem cells, tumor vasculature, and noncellular components of the TME in hepatocellular carcinoma. We also investigate their preclinical and clinical insights for primary liver cancer intervention, and explore the significance of using Wnt/β-catenin mutations as a biomarker to predict resistance in immunotherapy.
文献关键词：
中图分类号：
作者姓名：
Kaiting Wang;Xinyao Qiu;Yan Zhao;Hongyang Wang;Lei Chen
作者机构：
School of Life Sciences,Fudan University,Shanghai 200438,China;Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Institute of Metabolism&Integrative Biology(IMIB),Fudan University,Shanghai 200438,China;The International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China
文献出处：
引用格式：
[1]Kaiting Wang;Xinyao Qiu;Yan Zhao;Hongyang Wang;Lei Chen-.The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma)[J].癌症生物学与医学（英文版）,2022(03):305-318
A类：
noncellular
B类：
Wnt,catenin,signaling,pathway,tumor,microenvironment,hepatocellular,carcinoma,regulates,many,aspects,biology,studies,have,focused,role,this,cells,However,it,now,clear,that,development,metastasis,depend,two,between,cancer,their,thereby,forming,TME,In,review,discuss,how,cross,interactions,among,different,components,including,immune,stem,vasculature,We,also,investigate,preclinical,insights,primary,liver,intervention,explore,significance,using,mutations,biomarker,predict,resistance,immunotherapy
AB值：
0.556343
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