典型文献
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis
文献摘要：
Nonalcoholic steatohepatitis(NASH),as a severe form of nonalcoholic fatty liver disease(NAFLD),is characterized by liver steatosis,inflammation,hepatocellular injury and different degrees of fibrosis.The pathogenesis of NASH is complex and multifactorial,obesity and type 2 diabetes mellitus(T2DM)have been implicated as major risk factors.Glucagon-like peptide-1 receptor(GLP-1 R)is one of the most successful drug targets of T2DM and obesity,and its peptidic ligands have been proposed as potential therapeutic agents for NASH.In this article we provide an overview of the pathophysiology and management of NASH,with a special focus on the pharmacological effects and possible mechanisms of GLP-1 mimetics in treating NAFLD/NASH,including dual and triple agonists at GLP-1 R,glucose-dependent insulinotropic polypeptide receptor or glucagon receptor.
文献关键词：
中图分类号：
作者姓名：
Yan Chen;Ying-na Xu;Chen-yu Ye;Wen-bo Feng;Qing-tong Zhou;De-hua Yang;Ming-wei Wang
作者机构：
Department of Pharmacology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;The CAS Key Laboratory of Receptor Research and The National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Research Center for Deepsea Bioresources,Sanya 572025,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China
文献出处：
引用格式：
[1]Yan Chen;Ying-na Xu;Chen-yu Ye;Wen-bo Feng;Qing-tong Zhou;De-hua Yang;Ming-wei Wang-.GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis)[J].中国药理学报（英文版）,2022(05):1156-1166
A类：
peptidic
B类：
GLP,mimetics,potential,therapy,nonalcoholic,steatohepatitis,Nonalcoholic,NASH,severe,form,fatty,liver,disease,NAFLD,characterized,by,steatosis,inflammation,hepatocellular,injury,different,degrees,fibrosis,pathogenesis,complex,multifactorial,obesity,type,diabetes,mellitus,T2DM,have,been,implicated,major,risk,factors,Glucagon,like,receptor,one,most,successful,drug,targets,its,ligands,proposed,therapeutic,agents,In,this,article,we,provide,overview,pathophysiology,management,special,focus,pharmacological,effects,possible,mechanisms,treating,including,dual,triple,agonists,glucose,dependent,insulinotropic,polypeptide,glucagon
AB值：
0.651118
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